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Manipur Univ


Sivakumar Vijayaraghavalu

Designation: Associate Professor

Specialization: Genetics, Nanomedicine

Contact: 8925744196

Email: drshiva[ AT] manipuruniv.ac.in, livshiva [AT] gmail.com

M.Sc., (2001) & PhD (2006) University of Madras, Chennai, India
Post Doc. Fellow (2006-2007), Univ. of Nebraska Medical Center, Nebraska, USA.
Post Doc. Fellow (2007-2012), Cleveland Clinic Foundation, Ohio, USA.

Faculty Details Faculty List

 

Biographical Sketch

Sivakumar Vijayaraghavalu, Ph.D.,

INNOVATOR AWARDEE – From Cleveland Clinic Foundation (#2 rank in the world), Cleveland, Ohio, USA

Associate Professor, Department of Life Sciences (Zoology),

Manipur University (Central University), Manipur, India

&

Adjunct Professor, Department of Engineering Design

Indian Institute of Technology Madras (IITM), Chennai, India.

Phone – 8925744196 (M); E-mail - livshiva@gmail.com


 

PROFILE SUMMARY –

Peer Reviewed Publications – 50 (International Journals); Citations – 1373, h-index -17; i10 index- 22; Key Word - Sivakumar Vijayaraghavalu; Reference - Google Scholar.

 

Book Chapters – 9; Patents - Granted 10 (1 USA & 9 India); Filed – 10 Indian patents & 1 UK patent; Copyrights Granted – 3.


 

NATIONAL & INTERNATIONAL WORK EXPERIENCE

NATIONAL -

Academic position – Associate Professor, Department of Life Sciences (Zoology), Manipur University, Central University, Manipur India from Apr 2022 – till date

Administrative & academic position in Datta Meghe Institute of Medical Sciences (DMIMS; Deemed to be University), Sawangi (Meghe), Wardha, Maharashtra (Feb – Apr 2022; 2 months)

  • Deputy Director Clinical Research Division including Animal House Facility, Ayurveda Research, Central Research Facility – Stem cell/Regenerative Medicine and Nanomedicine.

Administrative and academic positions in Narayana Medical College, Nellore, AP (May 2020 – Jan 2022; 1 year and 8 months)

  • Professor and Head, Narayana Translational Research and Incubation Center, includes – Clinical Research Division, Central Animal Research Facility (CARF), Institute Innovation Council (IIC)

  • Deputy coordinator, International Students Cell

  • Member, Research Advisory Committee

Administrative and academic positions in Sri Ramachandra Institute of Higher Education and Research (SRIHER), Porur, Chennai, Tamil Nadu, India. (July 2019 – April 2020)

  • Associate professor and head, Herbal Indian Medicine Research Laboratory

  • Faculty, Clinical Research Division

INTERNATIONAL - USA

Administrative and academic position in Cleveland Clinic Foundation, Cleveland, Ohio, USA. Program – Cancer Nanomedicine & Case Western Reserve University (CWRU), Cleveland, Ohio, USA. (2006 – 2013 & 2016 – 2019; )

  • More than a decade of research experience in Cancer Nanomedicine program

  • Invented an epigenetic nanotherapeutics and patented the same

  • Received Innovator Award in 2011 from Cleveland Clinic Foundation for the indicated invention

  • Featured in Cleveland Clinic Foundation Alumni News Letter (May 2021 Lerner Trainee Newsletter.pdf (ccf.org)).

KINGDOM OF SAUDI ARABIA – KSA

Administrative and academic position in King Khalid University, Asir Province, Abha, KSA

College of Pharmacy, Department of Pharmaceutical Chemistry. (2013-2016)

  • Head/ coordinator – Continuous Pharmacy Education Office

  • Head – Exams committee

  • Member – Student Research Committee; - Lab committee & Purchase committee

  • Course Coordinator for Medicinal chemistry I, II & III

 

EDUCATIONAL QUALIFICATION

DEGREE/TRAINING, INSTITUTION & LOCATION

FIELD OF STUDY

M.Sc., (2001) & PhD (2006) University of Madras, Chennai, India.

Bio-Medical Genetics; & Interdisciplinary (Biomed. Genetics, Bio. Chem., Mol. Biology)

Post Doc. Fellow (2006-2007),

Univ. of Nebraska Medical Center, Nebraska, USA.

Cancer Nanomedicine

Post Doc. Fellow (2007-2012),

Cleveland Clinic Foundation, Ohio, USA.

Cancer Nanomedicine

  1. Positions

Positions and Employment:

Apr 2022 – till date

Associate Professor, Department of Life Sciences, Manipur University, A Central University, Manipur, India.

Feb – Apr 2022

(2 months)

Deputy Director Clinical Research Division (includes – Animal House Facility, Ayurveda Research, Central Research Facility – Stem cell/Regenerative Medicine, Nanomedicine lab) in DMIMS (DU) and deputy director clinical research division in Datta Meghe Medical College (DMMC), Wanadonghre, Nagpur, Maharashtra.

March 2021 – till date

Adjunct Professor, Department of Engineering Design, IIT – Madras,

Tamil Nadu.

May 2020 – Jan 2022

(1 year & 8 months)

 

Professor of Genetics and Head of Narayana Translational Research Centre, (Includes a clinical research division and central animal house facility), Narayana Medical College, Nellore, India.

July 2019 – Apr 2020

(9 months)

Associate Professor, Sri Ramachandra Institute of Higher Education & Research (Deemed to be University), Chennai, India.

July 2016 - July 2019

(3 years)

Staff (Research Assistant Prof.), Dept. of Bio Med. Engineering, Cleveland Clinic Foundation & Adjunct Assistant Professor, Cleveland Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.

June 2013 - Aug 2016

(3 years)

Assistant Prof., Dept. of Pharmaceutical Chemistry, King Khalid University (KKU), Kingdom of Saudi Arabia (KSA).

Jan 2013 - June 2013

(6 months)

Staff (Research Assistant Prof.), Dept. of Biomedical Engineering, Cleveland Clinic Foundation, Ohio, USA.

Feb 2007 – Dec 2012

 

Post-doctoral research fellow, Dept. of Biomedical Engineering, Cleveland Clinic Foundation, Ohio, USA.

 

  1. RESEARCH INTERESTS: Nanomedicine, Nano-biotechnology, Gene polymorphisms and Drug Resistance in cancer, Theranostics, Epigenetic nanotherapeutics, Nano-toxicology.

 

  1. INVITED TALKS - 18

  2. RESEARCH SUPPORT: As a post-doc and staff in Cleveland Clinic Foundation, Cleveland, Ohio, USA completed three RO1s and 2 Dept. of Defense major projects.

 

Clinical Research Projects completed in India – 8 (3 – Govt. agencies funded – 1 Ministry of AYUSH; 2 – IIT Madras, Tamil Nadu); 5 private company sponsored.

 

  1. Organized and conducted International and National Webinars/workshops as Convenor – 27 in number from 2020 –till date

 

  1. PROFESSIONAL SERVICE:

 

Journal Reviewer:

Mol. Med., Nano Rev., Nano Scale Res. Lett., Int. J. Nanomedicine, J. Nanomed Nanotechnol., Nanotech. Sci. Applications, Drug Deliv. Transl. Res., J. Biomater. Nanobiotechnol., Curr. Drug. Deliv., Drug Des. Devel. Ther., Drug Deliv. Lett., Int. J. Drug Discov., J.Cancer Sci.Ther., Breast Cancer Targets Ther., J. Biomark. Cancer, Curr. Oncol., Curr. Clin. Pharmacol., Cancer Growth Metastasis, Drug Target Insights, J. Bioprocessing Biotechniques, J. Cancer Ther., J. Carcinogeneis Mutagenesis, J. Environ. Anal. Toxicol., Lif. Sci., Stem cell Res. Ther., Onco. Targets Ther., Recent Pat. Drug Deliv. Formul., PLOSone; Frontiers in Neuroscience.

 

  1. Editorial Board Member:

 

  • Viral Immunology and Infection.

 

  • International Journal of Drug Discovery.

  1. Publications:

Peer reviewed publications:

 

  • Zainab Feroz, Sonia Tiwari, Sivakumar Vijayaraghavalu, Munish Kumar. GSTs genetic polymorphism, gene–environment interaction and association with gallbladder cancer risk in North Indian population: A case-controlled study. Journal of Cancer Research and Therapeutics, 2023; | DOI: 10.4103/jcrt.jcrt_1117_21

 

  • Thirumalaikumaran R, Prema S and Sivakumar Vijayaraghavalu. Influence of stachydrine on immunomodulation in mice. Int J Pharm Sci & Res, 2023; 14(8): 1000-08. doi: 10.13040/IJPSR.0975-8232.14(8).1000-08.

 

  • Deepesh, Dinesh; Khalid, Imran; Sivakumar, Vijayaraghavalu; M. Saifulla Khan; V. V. Nikesh. In vitro Evaluation of Antibiofilm Activity of Methanolic Leaf Extract of Azadirachta indica on Cariogenic Streptococcus mutans. J. Natural Remedies, 2023, 23, 275-281.

 

  • Anurag Mishra, Rishabh Kumar, Satya Narayan Mishra, Sivakumar Vijayaraghavalu (Corresponding Author), Neeraj Kumar Tiwari, Girish C. Shukla, Narasimman Gurusamy and Munish Kumar. Differential Expression of Non-Coding RNAs in Stem Cell
    Development and Therapeutics of Bone Disorders. Cells 2023, 12, 1159; IF – 7.666; ISSN 2073-4409.

 

  • Venkatesan Perumal, Arun Reddy Ravula, Agnieszka Agas, Manisha Kannan, Xiangshan Liu,
    Shanmuga Sundari I,     Sivakumar Vijayaraghavalu, James Haorah, Yuanwei Zhang and Namas Chandra. Transferrin-Grafted Albumin Nanoparticles for the Targeted Delivery of Apocynin and Neuroprotection in an In Vitro Model of the BBB. Micro 2023, 3, 84-106. https://doi.org/10.3390/micro3010008; ISSN: 2673-8023.

 

  • Perumal, Venkatesan, Arun Reddy Ravula, Agnieszka Agas, Aakaash Gosain, Aswati Aravind, Ponnurengam Malliappan Sivakumar, Shanmuga Sundari I, Karthik Sambath, Sivakumar Vijayaraghavalu, and Namas Chandra. Enhanced Targeted Delivery of Minocycline via Transferrin Conjugated Albumin Nanoparticle Improves Neuroprotection in a Blast Traumatic Brain Injury Model. Brain Sciences. 2023; 13(3):402. https://doi.org/10.3390/brainsci13030402.  ISSN: 2076-3425.

 

  • Fathima Banu Raza, Sivakumar Vijayaraghavalu, Ruckmani Kandasamy, Venkateshwaran Krishnaswami, Anand Kumar V. Microbiome and the inflammatory pathway in peri-implant health and disease with an updated review on treatment strategies. Journal of Oral Biology and Craniofacial Research, 2023, 13 (2); 84-91; ISSN - 2212-4268.

 

  • Sivakumar Vijayaraghavalu, Thirumalaikumaran Rathinam, Munish Kumar, Selvam Arjunan. Adverse Effects of Herbal Medicinal Plants - An Overview. European Journal of Molecular and Clinical Medicine, 2022, 9 (8), 2006 -2013; ISSN - 2515-8260.

 

  • Surya Prakash Rao and Sivakumar Vijayaraghavalu. Online classes design and delivery based on student responses. J. Indian Med Association, 2022, 120 (12); 48-56. ISSN -  0019-5847

 

  • Rishabh Kumar, Anurag Mishra, Priyanka Gautam, Zainab Feroz, Sivakumar Vijayaraghavalu, Eviania M Likos, Girish C Shukla, Munish Kumar. Metabolic Pathways, Enzymes, and Metabolites: Opportunities in Cancer Therapy. Cancers, 2022, 14, 5268. https://doi.org/10.3390/cancers14215268. ISSN - 2072-6694

 

  • Fathima Banu Raza, Sivakumar Vijayaraghavalu, Anand Kumar Vaidyanathan, Bone Morphogenetic Protein as Bone Additive around Dental Implant and its Impact on Osseointegration: A Systematic Review. J Dent Shiraz Univ Med Sci., 2022 September; 23(2 Suppl): 336-348. ISSN - 2345-6485.

 

  • Krishnaswami V, Sugumaran A, Perumal V, Manavalan M, Kondeti DP, Basha SK, Ahmed MA, Kumar M, Sivakumar Vijayaraghavalu (corresponding author). Nanoformulations - Insights Towards Characterization Techniques. Curr Drug Targets. 2022, 23 (14), 1330-1344. ISSN - 1389-4501.

 

  • Munish Kumar, Priyanka Gautam, Zainab Feroz, Sonia o Tiwari, Sivakumar Vijayaraghavalu, Girish C Shukla. Investigating the role of Glutathione S- transferase genes, Histopathological and molecular subtypes, Gene-Gene interaction and its susceptibility to Breast Carcinoma in Ethnic North- Indian population. Asian Pacific Journal of Cancer Prevention; 2022; 23 (10); 3481 – 3490; ISSN - 1513-7368.

 

 

  • Ritambhara, Rishabh Kumar, Maneesh Kumar Gupta, Priyanka Gautam, Sonia Tiwari, Sivakumar Vijayraghavalu, Girish C. Shukla, and Munish Kumar. Higher order genes interaction in DNA repair and cytokine genes polymorphism and risk to lung cancer in North-Indians. J Can Res Ther, (Epub, ahead of print) 2022, 18(4); 953-963; ISSN- 0973-1482.

 

  • Ritambhara, Sonia Tiwari, Sivakumar Vijayaraghavalu, Munish Kumar. Clinical response of Carboplatin based chemotherapy and its association to genetic polymorphism in lung cancer patients from North India- a clinical pharmacogenomics study. J Can Res Ther, 2022, 18 (1); 109 -118; ISSN- 0973-1482.

 

 

  • Thirumalaikumaran Rathinam, Chamundeeswari Duraipandian, Sivakumar Vijayaraghavalu. Development of herbal nano external formulation as ointment with Urena lobata extract and validation of its wound healing activity in experimentally induced open wounds in Swiss albino rats. Int. J. Pharm. Res. 2021; 12(1), 266-276; ISSN - 0975-2366.

 

  • Jishna JP, Selvam Arjunan, Sivakumar Vijayaraghavalu and K Ashwini Hegde. Determination of minimum inhibitory concentrations of common biocides to clinically significant klebsiella pneumonia. J. Global Trends Pharm Sci, 2021; 12 (1): 9076 – 9082; ISSN -2230-7346.

 

  • Rishabh Kumar, Priyanka Gautam, Sivakumar Vijayaraghavalu, Girish C Shukla, Munish Kumar. Imaging and future perspectives for diagnosis of complex diseases. Clinical Epidemiology and Global Health, 2020; 8 (4); 1119-1120; ISSN - 2213-3984.


 

  • Jessica Proulx, Chaitanya Joshi, Sivakumar Vijayaraghavalu, Manju Saraswathy, Vinod Labhasetwar, Anuja Ghorpade, Kathleen Borgmann. Arginine-Modified Polymers Facilitate Poly (Lactide-Co-Glycolide)-Based Nanoparticle Gene Delivery to Primary Human Astrocytes. Int J Nanomedicine, 2020, 15, 3639-3647. Impact factor (IF) – 4.471; ISSN -1176-9114.


 

  • Sivakumar Vijayaraghavalu, Yue Gao, Richard Rozic, Nima Sharifi, Ronald J Midura, Vinod Labhasetwar. Synergistic combination treatment to break cross talk between cancer cells and bone cells to inhibit progression of bone metastasis. Biomaterials (2020, 227, 119558. IF - 15.3; ISSN - 0142-9612.

 


 

 

  • Zainab Feroz, Sivakumar Vijayaraghavalu, Noohu Abdulla Khan, Narasimman Gurusamy, Girish C Shukla and Munish Kumar. Diabetes Mellitus: Classification, Genetic Association and Herbal Treatment. Archives of Diabetes and Obesity, 2019, 2(3); DOI: 10.32474/ADO.2019.02.000136; ISSN – 2638-5910.


 

  • Ritambhara, Sonia Tiwari, Sivakumar Vijayaraghavalu and Munish Kumar. Genetic polymorphisms of xenobiotic metabolizing genes (GSTM1, GSTT1, GSTP1), gene-gene interaction with association to lung cancer risk in North India – a case control study. Asian Pac. J. Cancer Prev. 2019, 20(9), 2707- 2714; ISSN - 1513-7368.

 

  • Ritambhara, Rishabh Kumar, Sonia Tiwari, Sivakumar Vijayaraghavalu, Girish C. Shukla and Munish Kumar. Prognostic value and risk associated with DNA repair genes, GSTs and cytokine genes polymorphism with susceptibility to lung cancer in North India. J. Can. Res. and Clinical Oncol. 2019, (Under Revision; IF - 3.332). ISSN -0171-5216.

 

  • Yue Gao, Sivakumar Vijayaraghavalu, Melinda Stees, Brian K. Kwon, Vinod Labhasetwar. Evaluating accessibility of intravenously administered nanoparticles at the lesion site in rat and pig contusion models of spinal cord injury. J. Control. Release, 2019, 302, 160 -168; ISSN - 0168-3659.

 

 

  • Sivakumar Vijayaraghavalu and Vinod Labhasetwar. Nanogel-mediated delivery of a cocktail of epigenetic drugs plus doxorubicin overcomes drug resistance in breast cancer cells. Drug delivery and translational research, 2018, 8(5), 1289 - 1299. ISSN -2190-393X.

 

  • Sivakumar Vijayaraghavalu (corresponding author) and Niranjali Devaraj, Hepato-protective activity of Plumbago zeylanica against diethylnitrosamine induced liver damage in male wistar albino rats – a chronic study. Pharmacie Globale; Int.J.Comprehensive Pharmacy, 2017, 8(4), 81-86. ISSN - 0976-8157.

 

  • Sivakumar Vijayaraghavalu (corresponding author), Kulanthaivel Thalakompudur Marappagounder, Noohu Abdulla Khan and Munish Kumar. Identification and Qualitative Phytochemical Evaluation of Alcoholic Root Extract of Plumbago zeylanica - An Oriental Medicinal Herb. Pharmacie Globale; Int. J. Comprehensive Pharmacy 2017, 8(4), 71 – 80; ISSN - 0976-8157.


 

  • Ritambhara, AnupKumar, Daya Shankar Lal Srivastava, Sivakumar Vijayaraghavalu and Munish Kumar. GSTM1/GSTT1 Gene Polymorphism in North Indian Population and their Association to Hypertension. Biosci., Biotech. Res. Asia, 2017, 14 (4). ISSN - 0973-1245

 

  • Safa Hassan Omer, Munish Kumar, Mohammed Al-Gathradhi, Sivakumar Vijayaraghavalu (Corresponding author). Evaluation of Self-Monitoring of Blood Glucose on Therapeutic Outcome of Type 2 Diabetes in Female Patients from Aseer Diabetic Center, Abha, Kingdom of Saudi Arabia. PharmacieGlobale; Int. J. Comprehensive Pharmacy, 2017, 8, 43 - 50. ISSN - 0976-8157

 

  • Rituraj Niranjan, Ritambhara, Kaushal Prasad Mishra, Sivakumar Vijayaraghavalu, Amit Goel and Munish Kumar. The Role of MicroRNA-21 and Autophagy in Liver Fibrosis. J. Liver, 2017, 6:3. ISSN - 2167-0889

 

  • Min-Sik Kim, Melinda Stees, BalaVamsi K. Karturi, Sivakumar Vijayaraghavalu, Richard E. Peterson, Gary L. Madsen, Vinod Labhasetwar. Pro-NP™ Protects Against TiO2 Nanoparticle-Induced Phototoxicity in Zebrafish Model: Exploring Potential Application for Skin Care. Drug Deliv. Transl. Res. 2017, 3, 372 - 382. ISSN - 2190-393X.

 

  • Raghavan Vijay, Sivakumar Vijayaraghavalu (shares first authorship), Peetla, Chiranjeevi, Yamada Masayoshi, Morisada Megan, Labhasetwar Vinod. Sustained Epigenetic Drug Delivery Depletes Cholesterol-Sphingomyelin Rafts from Resistant Breast Cancer Cells, Influencing Biophysical Characteristics of Membrane Lipids. Langmuir, 2015, 31, 1564 - 11573. ISSN - 0743-7463.

 

  • Narasimman Gurusamy, Sivakumar Vijayaraghavalu, Adel Al Hazzani, Harish Chandramoothy. The Enigma or Uric acid in Metabolic Syndrome. Diabesity 2015, 1, 29 - 30. ISSN - 2369-0569.

 

  • Safa Hassan Omer, Mohammad Ahmad Awwad Al Qahtani, Altieb Mohamed Altieb, AmgedAbdulwahabAwwad, Mohammed Al- Gathradhi and Sivakumar Vijayaraghavalu (Corresponding Author). Positive Impact of Self-monitoring of Blood Glucose on Diabetes Management in Male Patients with Type 2 Diabetes from Aseer Diabetic Center, Abha, Kingdom of Saudi Arabia. PharmacieGlobale: Int. J. Comprehensive Pharmacy 2015, 3, 1 - 5. ISSN - 0976-8157.

 

  • Chiranjeevi Peetla, Sivakumar Vijayaraghavalu and Vinod Labhasetwar. Biophysics of cell membrane lipids in cancer drug resistance: Implications for drug transport and drug delivery with nanoparticles. Invited review – published online in journal – Adv. Drug Deliv. Rev., 2013, 65, 1686 - 1698. ISSN - 0169409X.

 

  • Sivakumar Vijayaraghavalu and Vinod Labhasetwar. Efficacy of Decitabine-loaded Nanogels in Overcoming Cancer Drug Resistance is Mediated via Sustained DNA methyltransferase 1 (DNMT 1) Depletion. Cancer Lett. 2013, 331,122 - 129. IF - 6.491. ISSN - 0304-3835.

 

  • Sivakumar Vijayaraghavalu, Josephine Kam Tai Dermawan, Cheriyath Venugopalan and Vinod Labhasetwar. Highly Synergistic Effect of Sequential Treatment with Epigenetic and Anticancer Drugs to Overcome Drug Resistance in Breast Cancer Cells. Mol. Pharmaceutics 2013, 10, 337 - 352. IF - 4.556. ISSN -1543-8384.

 

  • Esaiki Muthu Shankar, Vijayakumar Velu, Vignesh Ramachandran, Sivakumar Vijayaraghavalu, Velayuthan Rukumani Devi. Recent Advances Targeting Innate Immunity–mediated Therapies against HIV-1 Infection. Microbiol. Immunol. (2012, 56, 497 - 505. (Invited Review). ISSN - 1348-0421.

 

  • Sivakumar Vijayaraghavalu, Chiranjeevi Peetla, Shan Lu and Vinod Labhasetwar. Epigenetic Modulation of the Biophysical Properties of Drug-resistant Cell Lipids to Restore Drug Transport and Endocytic Functions. Mol. Pharmaceutics, 2012, 9, 2730 - 2742. IF - 4.556. ISSN - 1543-8384.

 

  • Chiranjeevi Peetla, Radhika Bhave, Sivakumar Vijayaraghavalu, Andrew Stine, Vinod Labhasetwar. Drug Resistance in Breast Cancer Cells: Biophysical Characterization of and Doxorubicin Interactions with Membrane lipids. Mol. Pharmaceutics, 2010, 7, 2334 - 2348. IF - 4.556. ISSN - 1543-8384.

 

  • Jayme Horning, Sanjeeb Sahoo, Sivakumar Vijayaraghavalu, Jaspreet Vasir, Sanja Dimitrijevic, Tapan Jain, Amulya Panda and Vinod Labhasetwar. 3-D Tumor Model for In vitro Evaluation of Anticancer Drugs. Mol. Pharmaceutics 2008, 5, 849 - 862. IF - 4.556. ISSN - 1543-8384.

 

  • Murali Mohan Yallapu, Jaspreet Vasir, Tapan Jain, Sivakumar Vijayaraghavalu, and Vinod Labhasetwar. Synthesis, Characterization and Antiproliferative Activity of Rapamycin-loaded Poly (N-isopropylacrylamide) - based Nanogels in Vascular Smooth Muscle Cells. J. Biomed. Nanotechnol. 2008, 4, 16 - 24. ISSN -1550-7033.

 

  • Sivakumar Vijayaraghavalu, Derek Raghavan and Vinod Labhasetwar. Nanoparticles for Delivery of Chemotherapeutic Agents to Tumors. Curr. Opin. Investig. Drugs, 2007, 8, 477-484. (Invited Review). ISSN - 1472-4472.

 

  • Sivakumar Vijayaraghavalu and Niranjali Devaraj. Protective Effect of Plumbago zeylanica against Cyclophosphamide-Induced Genotoxicity and Oxidative Stress in Swiss Albino Mice. Drug Chem. Toxicol. 2006, 29, 279 - 288. ISSN - 0148-0545.

 

  • Sivakumar Vijayaraghavalu, Prakash Radhakrishnan, Murali Malliga Ramana, Devaraj Halagowder, Niranjali Devaraj. In vivo Micronucleus Assay and GST Activity in Assessing Genotoxicity of Plumbagin in Swiss Albino Mice. Drug chem. Toxicol. 2005, 28, 499 - 507. IF - 1.531. ISSN - 0148-0545.

 

  1. PATENT:

 

  1. US patent – granted; Title - “Nanogel-Mediated Drug Delivery” on February 19, 2019. Inventors – Dr. Sivakumar Vijayaraghavalu and Dr. Vinod Labhasetwar; US Patent # US 10206885B2.

 

  1. Indian Patent – Granted - title - A Novel photoplethysmograph IOT based device to determine the heart rate using volume measurement. P Karthigeyan, Satyajit Nayak, Satarupa Uttarkabat, Bibhuprasad Sahu, Saroj Kumar Rout, Sumita Mishra, Biswabandita Kar, Ashok Kumar Badamali, Sivakumar Vijayaraghavalu. The Patent Office Journal No. 50/2020 Dated 11/12/2020; page number – 61585-61842.

 

  1. Granted Indian Patent – title – Porcelain Teeth Holder for Test Scaling. Sivakumar Vijayaraghavalu, Raman Lakshmisundaram, Kameed khan Kasim Mohamed, ThoranavaviKuppusamy Gopal, Dasan Bindu and P Karthigeyan. Patent number - 336576-001; Certificate number – 103395; Date of Issue – 08/10/2021. Design Accepted and Published, Journal No is 43/2021 and Journal Date is 22/10/2021.

 

  1. Granted Indian Patent – title – Emergency Ventilator. Sivakumar Vijayaraghavalu, R. Thirumalaikumaran, Panchanathan Manokar, Arunan Murali, R. Krishna Kuma, and P. karthigeyan. Patent number – 337025-001; certificate number – 116380; Date of Issue – 17/08/2022. Design Accepted and Published, Journal No is 34/2022 and Journal Date is 26/08/2022

 

  1. Granted Indian Patent – title – Endocrine nano-distributor device for diabetes treatment. Sivakumar Vijayaraghavalu, Raman Lakshmisundaram, V. Bhopal Chandra, Thangaraj Kalaiyarasu, Vaiyapuri Manju, Arumugam Parthasarathy, Krishnaswamy Ezhilan Vivekanandan, P. Karthigeyan. Application number – 347615-001. Patent number – 347615-001; certificate number – 120027; Date of Issue – 15/12/2022; Design Accepted and Published, Journal No is 50/2022 and Journal Date is 16/12/2022.

 

  1. Granted Indian Patent – A Novel Pre-Symptomatic Breast Cancer Detection Device. Sivakumar Vijayaraghavalu, Noohu Abdullah Khan, Sultan M. Alshahrani, Mir Javid Iqbal, V. Krishnaraju, Kumar Venkatesan, E. Vigneshwaran, Sirajudeen Sheikh Alavudeen, Kumarappan Chidambaram, P. Karthigeyan. Application number - 351940-001; Patent number – 351940-001; certificate number – 124909; Date of Issue – 12/01/2023; Design Accepted and Published, Journal No is 02/2023 and Journal Date is 13/01/2023

 

  1. Granted Indian Patent – Serological Pipette. Sivakumar Vijayaraghavalu, Munish Kumar, Selvam Arjunan, P. Shanmugapandiyan, R. Thirumalaikumaran, Prashanthi R, P. Rajarajan, Zainab Feroz, Ritambhara, Raj Kumar, P Karthigeyan. Application number - 341565-001. Patent number – 341565-001; certificate number – 127124; Date of Issue – 25/01/2023. Design Accepted and Published, Journal No is 04/2023 and Journal Date is 27/01/2023.

 

  1. Granted Indian Patent – Sanitary Diaphragm Valve. Ashok Kumar Badamali; Sivakumar Vijayaraghavalu; Selvam Arjunan; S. Vijayanand; E. S. Challaraj Emmanuel; M Rajadurai; Gargee Mohanty; P Karthigeyan. Application number - 338163-001; Certificate number – 131552; Date of Issue – 29/01/2021. Design Accepted and Published, Journal No is 12/2023 and Journal Date is 24/03/2023.

 

  1. Granted Indian Patent – title – Lung Cancer Detection Machine using Mass Spectrometry. Ritambhara, Sivakumar Vijayaraghavalu, Munish Kumar, Neha Dobriyal, Kritika Dixit, Raman Lakshmisundaram, Subramani Srinivasan, Thanikkodi Dhanalakshmi, P.Karthigeyan. Application number - 346443-001. Certificate Number – 136864; Date of Issue – 23/05/2023; Design Accepted and Published, Journal No is 21/2023 and Journal Date is 26/05/2023

 

  1. Granted Indian Patent – title – Sanitary Pad Vending Machine. Ashok Kumar Badamali,
    Sivakumarvijayaraghavalu, Selvamarjunan, S. Vijayanand, E. S. Challaraj Emmanuel, M Rajadurai, Gargeemohanty, P. Karthigeyan. Design Number - 370185-001; Certificate Number – 137271; Date of Issue - 23/05/2023. Design Accepted and Published, Journal No is 21/2023 and Journal Date is 26/05/2023.

 

  1. An Indian Provisional Patent Filed for the invention titled - A Novel Nano-Magnesium and Pyridoxal 5’-Phosphate enriched supplement to Safely Combat Attention Deficit Hyperactivity Disorder in Children. Sarvepalli Vijayakumar, Sivakumar Vijayaraghavalu, Mohan Vasanth Kumar. Indian Patent Application Number - E-2/3185/2020-CHE. Narayana Medical College and Hospital, Chinthareddypalem, Nellore –524003, Andhra Pradesh, India.

 

  1. Indian Patent filed – title - Surgical Scalpel Handle. Sivakumar Vijayaraghavalu, Raman Lakshmisundaram, R. Thirumalaikumaran, N.Shanmuganathan, S. Madhan Kumar, N.Parthasarathy, ThoranavaviKuppusamy Gopal, R. Krishnakumar, and P Karthigeyan. Application number - 336399-001; Design application status -under technical examination process.

 

  1. Indian Patent filed – title – 3D Printable Anti-Covid -19 mask with eye protection. Munish Kumar, Sivakumar Vijayaraghavalu, Rishabh Kumar, ShambhuSharan Tripathi, Shailendra Kumar Mishra, Syed Ibrahim Rizvi, P Karthigeyan. Application number - 337867-001; Design application status - under technical examination process.

 

  1. Indian Patent filed – title – Dental Implant Box. N. Shanmuganathan, R. Thirumalaikumaran, Sivakumar Vijayaraghavalu, S. Madhan Kumar, N. Parthasarathy, S. Prema and P. Karthigeyan. Application number - 337388-001; Design application status - under technical examination process

 

  1. Indian Patent filed – title – Injectable Intramuscular Drug Delivery Device. Munish Kumar, Sivakumar Vijayaraghavalu, Selvam Arjunan, Zainab Feroz, Priyanka Gautam, Anurag Mishra, S Vijayanand, Challaraj Emmanuel E S, P. Rajarajan, U B Yadav, P. Karthigeyan. Application number - 338666-001; Design application status – under technical examination.

 

  1. Indian Patent filed – title – Automatic Pill Dispenser. K Durgaprasad, Sivakumar Vijayaraghavalu, A. Sai Saranya, Ravi Charishma, Sai Yamini Jamalla, Jonnalagadda Vijay Satya Teja, Adigopula Sujana, Peethala Harshini, Thanusha Kommerla, Rishabh Kumar, Munish Kumar, P Karthigeyan. Application number - 339246-001. Design application status – under technical examination.

 

  1. Indian Patent filed – title – Breast Cancer Detection Machine using Micro Calcifications. Biswabandita Kar, Raman Lakshmisundaram, Sivakumar Vijayaraghavalu, Jagadeshwar Radhakrishnamoorthy, Prabhu Kaliyaperumal, Ram Krishna Rao Mudiganti, P. Karthigeyan. Application number - 345149-001; Design application status – under technical examination.

 

  1. Indian Patent Filed – Title – A process of preparation of antibacterial activity and osteogenesis potential exhibiting IGF-1 loaded cationic PLGA nanoparticles. Fathima Banu Raza, Anand Kumar Vaidyanathan, Sivakumar Vijayaraghavalu. 27th July, 2023. Application number - 202341052157

 

  1. Indian Patent Filed – Title - A process of preparation of antibacterial activity and osteogenesis potential exhibiting IGF-1 loaded Neutral PLGA nanoparticles. Fathima Banu Raza, Anand Kumar Vaidyanathan, Sivakumar Vijayaraghavalu, Venkateswaran Krishnaswami, Ruckmani Kandasamy. 5th June, 2023. Application number – 202341046965.

 

  1. Indian Patent Filed – Title - A process of preparation of antibacterial activity and osteogenesis potential exhibiting IGF-1 loaded Anionic PLGA nanoparticles. Fathima Banu Raza, Anand Kumar Vaidyanathan, Sivakumar Vijayaraghavalu, Venkateswaran Krishnaswami, Ruckmani Kandasamy. 29th May, 2023. Application number - 202341046964

 

  1. COPYRIGHTS:

  • Granted - Indian Copyrights – title – A novel treatment for neuropsychotic disorders using herbal extracts of Sphaeranthus Indicus herb. Sivakumar Vijayaraghavalu, Noohu Abdullah Khan, Krishnaraju V, Kumar V, Vigneshwaran E. Registration number - L-106017/2021; Dairy number - 14342/2021-CO/L; August 3, 2021.

 

  • Granted - Indian Copyrights – title – A Novel Treatment of Chronic Obstructive Pulmonary Disease Using Solanum Surratense and Picrorhiza Kurroa Herbs. Sivakumar Vijayaraghavalu, Noohu Abdulla Khan, V.Krishnaraju, Kumar V, E.Vigneshwaran, Sirajudeen Sheikh Alavudeen, Kumarappan Chidambaram. Registration number - L-107867/2021; Dairy Number - 20129/2021-CO/L; August 21, 2021.

 

  • Granted - Indian Copyrights – title - A Novel Therapuetic Treatment of Endocrine
    Tumour using Emblica Officinalis and Kanchnaar Guggul Herbs. Sivakumar Vijayaraghavalu, R. Thirumalaikumaran, S. Prema, Selvam arjunan, Jiju v, Bansidhar Mulia, Pradyumna Kishore Behera, Dr. Biswa Bandita Kar, Mr. Bibhudatta Sahoo, Mr. Chandan Kumar Mohapatra. Registration number - L-111850/2022; Dairy Number - 28098/2021-CO/L; February 10, 2022

 

  1. BOOK CHAPTER:

 

  1. Venkateshwaran Krishnaswami, Soumya Parashar, Balakrishnan Natarajan, Borish Loushambam, Sivakumar Vijayaraghavalu. Vol – 4 Chapter 17 - Calcium-dependent and -independent phospholipases and apoptosis, Editor: Sajal Chakraborti, Phospholipases in Physiology and Pathology, Academic Press, 2023, Pages 279-291, ISBN 9780323956871, https://doi.org/10.1016/B978-0-323-95698-7.00023-1. https://www.sciencedirect.com/science/article/pii/B9780323956987000231

 

  1. Sanjay Yadav, Anurag Mishra, Satya Narayan Mishra, Rishabh Kumar, Sivakumar Vijayaraghavalu, Munish Kumar, Chapter 10 - Phospholipases and their metabolites in cancer, Editor(s): Sajal Chakraborti, Phospholipases in Physiology and Pathology, Academic Press, 2023, Pages 173-198, ISBN 9780323956871, https://doi.org/10.1016/B978-0-323-95697-0.00016-9.

 

  1. Basavaraju, A.M., Murugan, R., Keshava, R., Sivakumar Vijayaraghavalu, Swamy, M.K., Arjunan, S. (2022). DNA Barcoding for the Substantiation of Herbal Products. In: Swamy, M.K., Kumar, A. (eds) Phytochemical Genomics. Springer Nature (ISBN - 978-981-19-5779-6), Singapore. https://doi.org/10.1007/978-981-19-5779-6_27; Pages 651-668.

 

  1. Anurag Mishra, Sivakumar Vijayaraghavalu, Munish Kumar (2022). Chapter 24 - Cardiovascular disorders and herbal medicines in India. Editor(s): Maryam Sarwat, Hifzur Siddique. Book title - Herbal Medicines. Academic Press (ISBN 9780323905725), Pages 525-555.

 

  1. Venkateshwaran Krishnaswami, Munish Kumar, Sivakumar Vijayaraghavalu (2022). Chapter title - Advances in Epigenetics for Crop Improvement and Sustained Agriculture. Book title - Plant Genomics for Sustainable Agriculture. Springer Nature Singapore, ISBN 978-981-16-6973-6, Pages 351-370.

 

  1. Priyanka Gautam, Ritambhara, Sivakumar Vijayaraghavalu and Munish Kumar (2022). Chapter title - RNA interference technology in plants: Mechanisms and applications in crop improvement; book title - Plant Genomics for Sustainable Agriculture. Springer Nature Singapore, ISBN 978-981-16-6973-6, Pages 265-290

 

  1. Sree Raju Nikhishaa, Krishnaswami Venkateshwaran, Sivakumar Vijayaraghavalu, Kandasamy Ruckmani (2020). Transdermal and bioactive nanocarriers. Nanocosmetics 1st Edition, Fundamentals, Application and Toxicity, Editors, Arun Nanda, Sanju Nanda, Tuan Anh Nguyen, Susai Rajendran,Yassine Slimani, Elsevier (eBook ISBN: 9780128222850), pages 17-25

 

  1. Sivakumar Vijayaraghavalu, Ritambhara Zainab, Himanshu K Prasad, Munish Kumar (2019). Treatment and Recycling of Wastewater from Winery. In: Singh R., Singh R. (eds) Advances in Biological Treatment of Industrial Waste Water and their Recycling for a Sustainable Future. Applied Environmental Science and Engineering for a Sustainable Future. Springer, Singapore (ISBN 978-981-10-1865-7), Pages 167-197.

 

  1. Ritambhara Zainab, Sivakumar Vijayaraghavalu, Himanshu K. Prasad and Munish Kumar (2019). Treatment and Recycling of Wastewater from Dairy Industry. In: Singh R., Singh R. (eds) Advances in Biological Treatment of Industrial Waste Water and their Recycling for a Sustainable Future. Applied Environmental Science and Engineering for a Sustainable Future. Springer, Singapore (ISBN 978-981-10-1865-7), Pages 91-115.

 

  1. HONORS AND AWARDS

 

  • Adjunct Professor, Dept. of Engineering Design, IIT Madras, Chennai, TN.

 

  • Core committee member, Department of Medical Sciences and Technology, IIT Madras, Chennai, TN.

 

  • Invited to draft syllabus for B.S Medical Sciences Program, IIT Madras, Chennai, TN (2022 -2023)

 

  • Award – Top 10 Educators of the Year 2021-2022; International Institute of Organized Research (I2OR), Punjab, India & Melbourne, Australia. 25 November, 2022.

 

  • Preeminent Academic Excellence Award, IRSD Award 2022, 8th International Conference on Interdisciplinary Research for Sustainable Development, sponsored by Center for Smart Modern Construction, Western Sydney University, Australia, IIT Bombay Spoken Tutorial, Green Thinkerz, I2OR India, Sustainable Cosmos and the Intelligent Indian. 30 September, 2022.

 

  • Manipur University Teachers Association (MUTA) – EC member and Zoology department representative (2022-2023).

 

 

  • Guest of honor in TEQIP-II Sponsored Two Weeks Faculty Development Program on Advances in Nanotechnology and Analytical Instrumentation in Health Sciences (June 2016); Dept of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational Research, Anna Univ. Trichy, TN, India.

 

  • Guest of honor in national pharmacy week valedictory function, Narayana College of Pharmacy, Nellore, Nov. 27, 2021

 

  • Received Three Best Teacher Award from KKU, KSA, 2014-2015.

 

  • Received appreciation award for online teaching using Blackboard software, KKU, KSA, 2016.

 

  • Certificate of recognition as educator in North America by Covington’s Who’s Who in 2012.

 

  • Biography selected in Marquis Who's Who in America 2013-2016.

 

  • Innovation Ambassador, certified by - Ministry of Education, Innovation Cell, Govt. of India

 

  • 2011 INNOVATOR AWARD from Cleveland Clinic Foundation, Cleveland, Ohio, USA for inventing decitabine-nanogel delivery system.

 

  • Received Earn while Learn Fellowship from University of Madras during Ph.D.