Dr Thiyam Ramsing Singh

Designation: DBT - Ramalingaswami Re-entry Scientist

Specialization: Genomic instability and DNA repair

Contact: +91-9856593232

Email: ramsing1thiyam [AT] gmail.com

M.Sc (Manipur University)

Ph.D. (Central Drug Research Institute, Lucknow), India

Website: http://manipuruniv.ac.in/faculty/76

PROFESSIONAL EXPERIENCES:

Name of the employer Post Held Period
Manipur University, India DBT-Ramalingaswami Fellow August 2012 – till date
Cincinnati Children’s Hosp. Med. Center.  USA Research Associate Dec.2004-Aug.2012
University of Maryland. USA Research Fellow Feb.2002-Dec.2004

 

AWARDS AND HONORS:

1.  Ramalingaswami Re-entry Fellowship,  Department of Biotechnology ( INDIA,  2012)

2.  Discovery Award presented by Fanconi Anemia Research Foundation, USA, for the discovery of FANCM gene. (2005).

3.  Gold Medal Award presented by Manipur University, India for scoring first class first in Master Degree in Biochemistry. (1998).

TEACHING EXPERIENCE:

  • Course teacher for Genomics, Proteomics, and genetic engineering.

NUMBER OF Ph.D. STUDENTS GUIDING:

        Two (2)

NUMBER OF Ph.D. STUDENTS GUIDED:

       Three(3)

CURRENT PROJECTS: 

Sl. No. Agency Period Grant/Amount (INR)
1 DBT 2012-2022 160.56 lakhs  (including fellowship)
2 DBT 2015-2018 69 lakhs
3 DBT-IBSD 2017-2019 60.4 lakhs

LIST OF SELECTED PUBLICATIONS:

  1. Sharma AL, Singh TR, Singh LS. Understanding of HIV/AIDS in the international border area, Manipur: Northeast India Epidemiology and Infection. 2019 Jan;147:e113. doi: 10.1017/S0950268818003564.. (Journal Impact factor: 2.0)

  1. Devi MS, Meiguilungpou R, Sharma AL, Anjali C, Devi KM, Singh LS, Singh TR. Spindlin docking protein (SPIN.DOC) interaction with SPIN1 (a histone code reader) regulates Wnt signaling Biochemical Biophysical Research Communication. 2019 Feb 22. pii: S0006-291X(19)30291-8. doi: 10.1016/j.bbrc.2019.02.096. [Epub ahead of print] (Journal Impact factor: 2.56)

  1. Sharma AL, Singh TR, Singh LS. Antiretroviral resistance, genotypic characterization and origin of Human Immunodeficiency Virus among the infected wives of Intravenous drug users in Manipur Scientific Reports. 2018 Oct 12;8(1):15183. (Journal Impact factor:4.1)

  1. Singh SP, Nongalleima K, Singh NI, Doley P, Singh CB, Singh TR, Sahoo D. Zerumbone reduces proliferation of HCT116 colon cancer cells by inhibition of TNF-alpha. Scientific Reports. 2018 Mar 6;8(1):4090. doi: 10.1038/s41598-018-22362-1. (Journal Impact factor:4.1 )

  1. Sharma AL, Singh TR, Devi KR, Singh LS. Molecular epidemiology of HIV-1 among the HIV infected people of Manipur, Northeastern India: Emergence of unique recombinant forms. J Med Virol. 2017 Jun; 89(6):989-999. (Journal Impact factor:2.4)

  1. Sharma AL, Singh TR, Devi KR and Singh LS. Prevalence of drug resistance associated mutations among the Retroviral Therapy Exposed HIV-I infected individuals in Manipur, Northeastern India. Current HIV Research 2016;14(4):360-70. (Journal Impact factor:1.5)

  1. Singh TD, Meitei HT, Sharma AL, Robinson A, Singh LS, Singh TR. Anticancer properties and enhancement of therapeutic potential of cisplatin by leaf extract of Zanthoxylum armatum DC Biological Research. 2015 Aug 20;48:46. (Journal Impact factor:2.3)

  1. Deepak L, Singh AR, Sharma TD, Singh TS, Singh TR, Singh LS. Evaluation of Risk Factors for Nasopharyngeal Carcinoma in a High-risk Area of India; Northeastern Region Asian Pac J Cancer Prev 2015, 16 (12), 4927-4935. (Journal Impact factor:2.1)

  1. Zhao Q, Saro D, Sachpatzidis A, Singh TR, Schlingman D, Zheng XF, Mack A, Tsai MS, Mochrie S, Regan L, Meetei AR, Sung P, Xiong Y. The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes. Nature Communication. 2014 Jan 3;5:2987. (Journal Impact factor:12.3)

  1. Park JY, Singh TR, Nassar N, Zhang F, Freund M, Hanenberg H, Meetei AR, Andreassen PR. Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair. Oncogene.  (2014) 33, 4803–4812; doi:10.1038/onc.2013.421. (Journal Impact factor:6.8)

  1. Pradhan A, Singh TR, Ali AM, Wahengbam K, Meetei AR. Monopolar Spindle 1 (MPS1)-dependent Phosphorylation of RecQ mediated genome instability protein 2 (RMI2) at Serine 112 is Essential for BLM-Topo III α-RMI1-RMI2 (BTR) complex function upon spindle assembly checkpoint (SAC) activation during mitosis. J Biol Chem. 2013 Nov 22; 288(47): 33500–33508. (Journal Impact factor:4.2)

  1. Singh TR, Ali AM, Paramasivam M, Pradhan A, Wahengbam K, Seidman M, and Meetei AR. ATR-dependent phosphorylation of FANCM at Serine 1045 is essential for FANCM functions. Cancer Research 2013 Jul 15; 73(14): 4300–4310. (Journal Impact factor:9.1)

  1. Ali AM, Pradhan A, Singh TR, Du C, Li J, Wahengbam K, Grassman E, Auerbach AD, Pang Q, Meetei AR. FAAP20: a novel ubiquitin-binding FA nuclear core complex protein required for functional integrity of the FA-BRCA DNA repair pathway. Blood. 2012 Apr 5; 119(14): 3285–3294. (Journal Impact factor:13.1)

  1. Singh TR, Saro D, Ali AM, Zheng X, Du Ch, Killen MW, Sachpatzidis A Wahengbam k, Pierce AJ, XiongY, Sung P, Meetei AR. MHF1-MHF2, a Histone-Fold-Containing Protein Complex, Participates in the Fanconi Anemia Pathway via FANCM. Molecular Cell. 37, 879-886, March 26, 2010 (Featured Article; Highlighted with a Preview in the same issue: 749-751). (Journal Impact factor:14.2)

  1. Wang F, Yang Y, Singh TR, Busygina V, Guo R, Wan K, Wang W, Sung P, Meetei AR, Lei M. Crystal Structures of RMI1 and RMI2, Two OB-fold Regulatory Subunits of BML Complex. Structure. 2010 Sep 8; 18(9):1159-70. (Journal Impact factor:5.6)

  1. Singh TR, Bakker ST, Agarwal S, Jansen M, Grassman E, Godthelp BC, Ali AM, Du Ch, Rooimans MA, Fan Q, Wahengbam K, Steltenpool J,. Andreassen PR, Williams DA, Joenje H, Winter JP and Meetei AR. Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M. Blood. 2009 Jul 2; 114(1):174-80. (Journal Impact factor:13.1)

  1. Singh TR, Ali AM, Busygina V, Raynard S, Fan Q, Du Ch, Anderssen PR, Sung P, Meetei AR. BLAP18/RMI2, a novel OB-fold containing, is essential component of Bloom helicase-double Holliday junction dissolvasome. Genes & Development, 2008 22: 2856-2868. (Highlighted by Genes & Dev. 22:2737-2742. 2008; Nature Reviews Molecular Cell Biology 9, 920-921.2008 and Nature 456, 453-454). (Journal Impact factor:9.4)

  1. Meetei AR, Medhurst AL, Ling C, Xue Y, Singh TR, Bier P, Steltenpool J, Stone S, Dokal I, Mathew CG, Hoatlin M, Joenje H, de Winter JP, Wang W. A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation GroupM. Nature Genetics. 2005 Sep; 37 (9): 958-63. (Highlighted with News and Views in the same issue, 37, 921 – 922. (Journal Impact factor:27.1)

  1. Singh TR, Shankar S, Srivastava RK. HDAC inhibitors enhance the apoptosis-inducing potential of TRAIL in breast carcinoma. Oncogene. 2005 Jul 7; 24 (29): 4609-23. (Journal Impact factor:6.8)

  1. Shankar S, Singh TR, Srivastava RK. Ionizing radiation enhances the therapeutic potential of TRAIL in prostate cancer in vitro and in vivo. Prostate. 2004 Sep 15; 61 (1) 35-49. (Journal Impact factor:3.5)

  1. Shankar S, Singh TR, Chen X, Thakkar H, Firnin J, Srivastava RK. The sequential treatment with ionizing radiation followed by TRAIL/Apo-2L reduces tumor growth and induces apoptosis of breast tumor xenografts in nude mice. Int. J Oncol. 2004 May, 24(5): 1133-40 (Journal Impact factor:3.1)

  1. Singh TR, Shankar S, Chen X, Asim M, Srivastava RK. Synnergistic interactions of chemotherapeutic drugs and tumor necrosis factor-related apoptosis-inducing ligand/Apo-2 ligand on apoptosis and regression of breast carcinoma in vivo. Cancer Research, 2003 Sep 1; 63(17): 5390-400. (Journal Impact factor:9.1)

  1. Singh N, Singh RT, Sundar S. Novel mechanism of drug resistance in kala azar field isolates. The Journal of Infectious Diseases, 2003 Aug 15; 188(4):600-7; 2003. (Journal Impact factor:5.2)

 

 

 

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