Dr Md Hamidur Rahaman

Designation: Assistant Professor

Specialization: Biophysical Chemistry, Molecular Biology, Molecular Dynamics

Contact: +91-9863518139

Email: rahamanh [AT] manipuruniv.ac.in, hamidur2006 [AT] gmail.com

MSc, JRF, Ph.D.

Website: http://manipuruniv.ac.in/faculty/75

Research Summary

My area of research is biophysical studies of protein structure, function, folding and misfolding. The effect of post-translation modification and chemical modification on proteins is investigating in our lab. We also engage in investigating how small molecule compounds affect native protein structure, stability and enzymatic catalysis.

Now the main active research is to reveal the structure-function relationships and physiological role of the protein, Peroxiredoxin 6 (Prdx6). Prdx 6 is unique as a bifunctional enzyme with both glutathione peroxidase and phospholipase A2 activities. We are doing research on the structural insight of Prdx6 such as the mechanism of the activities, physiological effect of oligomerization, repair of peroxidised membranes and normal turnover of lung surfactant phospholipids.

 

Area of Interest

  • Structure and Functional study of antioxidant enzymes

  • Molecular biology of communicable Diseases

 

Specialization Area

  • Biophysical Chemistry

  • Molecular Biology

  • Molecular Dynamics

 

Professional training and research experiences

Name of Employer

Position Held

Period

Manipur University, India

Assistant Professor

March 2012-

IFEM, University of Pennsylvania Perelman

School of Medicine, Philadelphia, USA

 

Postdoctoral Research Fellow

March 2010-Feb 2012

 

Biological chemistry, Chemistry Department, Umeå

University, Sweden

 

Postdoctoral Research Fellow

Jan 2009-Dec2009

 

Award and Honors.

  1. Qualified National eligibility Test (NET) July 2003, for Lectureship and Junior Research Fellow in Indian Universities (JRF-UGC) in Life Sciences.

  2. Awarded second best poster presentation award at RRR 2011, University of Pennsylvania, Philadelphia

  3. Summer Research Fellowship award by Indian Academy of Sciences, Bangalore, 2017

PhD Schloar

  1. Ms. Sharifun Shahnaj

  2. Ms.Pushpa Kakchingtabam, DST-Inspire Fellow

  3. Mr. Mohd Ajmal, CSIR-JRF

  4. Mr. Wungnaopam N, CSIR-JRF

RESEARCH ASSOCIATE:

  1. Dr. Marina Warepam (ICMR-RA)

  2. Dr. Kh. Herojit Singh, (DBT-RA)

Selected List of Publications

[1] The Med8, Med18 and Med20 subunits of the Mediator head domain are interdependent on each other for folding and complex formation.

ZakiShaikhibrahim, HamidurRahaman, PernillaWittung-Stafshede and Stefan Björklund PNAS, 2009 Dec; 106(49): 20728–20733. (Impact Factor: 9.54, Cite Score: 8.59)

 

[2]Sequence and stability of the goat cytochrome c

Hamidur Rahaman, Md Khurshid Alam Khan, Md. Imtaiyaz Hassan, Mohd. Wahid, S. Baskar Singh, Tej P. Singh, Ali Akbar Moosavi-Movahedi and Faizan Ahmad, Biophys Chem.2008 Nov;138(1-2):23-8. (Impact Factor: 1.87, Cite Score: 2.08)

 

[3] A single mutation induces molten globule formation and a drastic destabilization of wild type Cytochrome c

Md. Khurshid Alam Khan, Utpal Das, Hamidur Rahaman, Md. Imtaiyaz Hassan, Alagiri Srinivasan, Tej P. Singh, and Faizan Ahmad. J Biol. Inorg Chem. 2009 Jun; 14(5):751-60. . (Impact Factor: 2.952)

 

[4] Conformational and Thermodynamic Characterization of the Premolten Globule State Occurring during Unfolding of Molten Globule State of Cytochrome-c by Lithium Chloride.

Md. Khurshid Alam Khan,Hamidur Rahaman, Utpal Das, Md. Imtaiyaz Hassan, A. Srinivasan,Tej P. Singh, Ali A. Moosavi-Movahedi, and Faizan Ahmad. J BiolInorg Chem. 2010;15(8):1319-29. (Impact Factor: 2.952)

 

[5] Conformational and Thermodynamic Stability of Premoltenand Molten Globule States of Mammalian Cytochromes-c".

MdKhurshidAlamKhana, HamidurRahaman and Faizan Ahmad.Metallomics. 2011 Apr;3(4):327-38. (Impact Factor: 4.06 , Cite Score:4.01)

 

[6] Increased Phospholipase A2 Activity with Phosphorylation ofPeroxiredoxin 6 Requires a Conformational Change in the Protein.

HamidurRahaman, Suiping Zhou, Chandra Dodia, Sheldon I. Feinstein,Shaohui Huang, David Speicher, and Aron B. Fisher.Biochemistry, 2012; 51, 5521−5530. (Impact Factor: 2.99 , Cite Score:2.92)

 

[7]Evidence of non-coincidence of normalized sigmoidal curves of two different structural properties for two-state protein folding/unfolding.

HamidurRahaman, Md. KhurshidAlam Khan, Md. Imtaiyaz Hassan, Asimul Islam and Faizan Ahmad, Journal of Chemical Thermodynamics, 2013:58, 351-358. (Impact Factor: 2.19 , Cite Score:2.58)

 

[8] Heterogeneity of Equilibrium Molten Globule state of Cytochrome c induced by Weak Salts Denaturants under physiological condition

HamidurRahaman, Md Khurshid Alam Khan, Imtaiyaz Hassan, Asimul Islam, Ali A. Moosavi-Movahedi and Faizan Ahmad. PlosOne. April, 2015.DOI:10.1371/journal.pone.0120465. (Impact Factor: 2.76 , Cite Score:3.01)

 

[9] Hyperoxidation of Peroxiredoxin 6 Induces Alteration from Dimeric to Oligomeric State

Sharifun Shahnaj; Rimpy Kaur Chowhan; Potshangbam Angamba Meetei; Pushpa Kakchingtabam; Khundrakpam Herojit Singh; Laishram Rajendrakumar Singh; Potshangbam Nongdam; Aron B. Fisher; Hamidur Rahaman, Antioxidants, 8(2), 2019, 33. (Cite Score:3.56)

[10] Hyperoxidation of Peroxiredoxin 6 Induces Alteration from Dimeric to Oligomeric State
Hamidur Rahaman
Sharifun Shahnaj; Rimpy Kaur Chowhan; Potshangbam Angamba Meetei; Pushpa
Kakchingtabam; Khundrakpam Herojit Singh; Laishram Rajendrakumar Singh; Potshangbam
Nongdam; Aron B. Fisher; Hamidur Rahaman, Antioxidants, 8(2), 2019, 33. (Impact
Fcator: 4.52, Cite Score:4.88)


[11] The anti-oxidant enzyme, Prdx6 might have cis-acting regulatory sequence (s)
Sharifun Shahnaj, Angamba Meetei Potshangbam, Rimpy Kaur Chowhan, Zahoor Ahmad
Parray, Pushpa Kakchingtabam, Anju Kumari, Asimul Islam, Aslam Khan, Laishram
Rajendrakumar Singh, Hamidur Rahaman, International Journal of Biological
Macromolecules
, 149, 2020, 1139-1150. (Impact Factor: 4.78, Cite Score:4.97)


[12] N-Acetylaspartate Is an Important Brain Osmolyte
Marina Warepam, Khurshid Ahmad, Safikur Rahman, Hamidur Rahaman, Kritika Kumari,
Laishram Rajendrakumar Singh, Biomolecules, 2020, 10 (2), 286. (Impact Factor: 4.69, Cite
Score: 5.72)


[13] Effect of Bi contents on key physical properties of NiO NPs synthesized by flash
combustion process and their cytotoxicity studies for biomedical applications.
Aslam Khan, Mohd Shkir, Essam H Ibrahim, Mona Kilany, S AlFaify, MA Sayeed, Ahmed
Mohamed El-Toni, Ali Aldalbahi, Hamidur Rahaman, Mohammad Mairaj Siddiquei,
Ceramics International, 2020. (Impact Factor: 3.45 , Cite Score:3.5)

 

 

Book Published

Pharmacological Chaperones in Protein Aggregation Disorder by Rahaman, H. et al., a chapter published in Springer published Book entitled Proteostasis and Chaperone Surveillance edited by Singh, Laishram Rajendrakumar in 2016.

 

 

Presentation and Conferences

  1. Poster Presentation at National Symposium on Advances in Clinical Biochemistry-Biomarkers, Molecular Diagnosis and Quality Assurances & UPACBICON (Nov 15-16, 2008) organised by Dept. Of Biochemistry, Faculty of medicine, JNMC, Aligarh Muslim University, Aligarh, India.

Sequence and stability of the goat cytochrome c”, Hamidur Rahaman, Md Khurshid Alam Khan and Faizan Ahmad.

  1. Participated at Interdisplinary science Conference-2008 Mathematics in Biology held on 2008, CIRBSc, JamiaMilliaIslamia, New Delhi, India.

  1. Poster Presentation at Experimental Biology 2011, Washington DC

Phosphorylation ofperoxoredoxin6 changes its conformational and increase its binding to phospholipids”, HamidurRahaman, Suiping Zhou, Tea Shuvaeva, Sheldon I. Feinstein and Aron B. Fisher.

 

  1. Poster Presentation at RRR 2011, University of Pennsylvania Perelman School of Medicine, Philadelphia

Phosphorylation of Prdx6 mediated by MAPkinase induces conformational change with concomitant increase in its phospholipase A2 acitivity”, HamidurRahaman, Suiping Zhou, Tea Shuvaeva, Sheldon I. Feinstein and Aron B. Fisher.

 

  1. Poster Presentation at Experimental Biology 2012, san diego, California. “Increased Phospholipase A2 Activity with Phosphorylation of Peroxiredoxin 6 Requires a Conformational Change in the Protein.”Hamidur Rahaman, Suiping Zhou, Tea Shuvaeva, Sheldon I. Feinstein and Aron B. Fisher.

  2. Participated as resource person at National Symposium on “Frontiers of Biophysics, Biotechnology & Bioinformatics” & 37th Annual Meeting of Indian Biophysical Society (IBS) January 13-16, 2013.

  3. Oral presentation at National Conference on Recent Trends in Protein Structural Biology-2013 (NCRTPSB-2013) December 16-18, 2013.

  4. Oral presentation at National Conference on Protein Structure and Dynamics in Health and Agriculture, November 3-4, 2017.


 

List of cDNA sequences submitted to GenBank

(1) Capra hircus mitochondrial cytochrome c mRNA, partial cds; nuclear gene for mitochondrial produc, ACCESSION No. DQ176429, NCBI Genbank, Rahaman,M.H., Baskar Singh,S., Srinivasan,A., Ahmad,F., Baig,M.A. And Singh,T.P.

 

List of Research projects undertaken


 

Sl. No.

Funding Agent

Period

Grant/Amount (INR)

1.

DBT

2013-16

54.33 lakhs

2.

DBT

2016-19

46.30 lakhs


 

Member of Scientific Society

  1. Society of Biological Chemists, India

  2. Indian Biophysical Society (IBS), India.