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Manipur Univ


Takhellambam Chanu Machathoibi

Designation: Assistant Professor

Specialization: Recombinant DNA Technology

Contact:

Email: machathoibiASTM[AT]manipuruniv.ac.in/ machathoibi2008[at]gmail.com

M.Sc., Ph.D.

Website: http://manipuruniv.ac.in/faculty/73

Faculty Details Faculty List

TAKHELLAMBAM CHANU MACHATHOIBI, M.Sc., Ph. D

Assistant Professor

Department of Biotechnology

Manipur University, Canchipur

Imphal west—795003, Manipur, India.

Email: machathoibiASTM[AT]manipuruniv.ac.in/ machathoibi2008[at]gmail.com

 

Research Area: Recombinant DNA Technology, Medical Biotechnology, Animal Behavior, Behavioral Biology

 

Education:

  • B. Sc. (Zoology Hons.), DM college, Manipur University, Manipur

  • M. Sc. (Biotechnology), Jamia Millia Islamia, Delhi

  • Ph. D. (Biotechnology). Manipur University, Manipur

 

Awards:

  • CSIR NET under Lectureship category (2005)

  • CSIR NET under Lectureship (LS) and Junior Research Fellowship category (JRF) (2007)

 

Positions held:

  • Assistant Professor: Department of Biotechnology, Manipur University, Imphal, India. (2009-till date)

  • Visiting Scientist: University of Cincinnati, College of Medicine, Cincinnati, Ohio, USA. (2022-2023)

  • Junior Research Fellow: National Institute of Pathology, ICMR, Safdarjung, New Delhi, India. (2008-2009)

  • Lecturer: S. Kula Women’s College, Manipur, India. (2007-2008)

 

Publications

  1. Singh AS, Naqvi AR, Chanu MT. (2026). Microglial, astrocytic, oligodendrocyte, B-/T-cell and neutrophil dysregulation in neuroinflammation of Alzheimer's disease and related dementias. J Psychiatr Res, 195:225-243. DOI: 10.1016/j.jpsychires.2026.01.050

  2. Singh AS and Chanu MT. (2026). Immediate early genes Egr-1, Hr-38 and Kakusei function throughout the entire foraging period: An update study on honeybees. World Journal of Advanced Research and Review, 30:112-124. DOI: https://doi.org/10.30574/ wjarr.2026.30.2.1189

  3. Singh AS, Naqvi AR, Chanu MT. (2025). Neuroinflammation and progress in clinical trials for the treatment of Alzheimer’s disease and related dementias: An update. Innovative Medicines & Omics, 2:36–50. DOI: 10.36922/IMO025050007.

  4. Singh AS and Chanu MT. (2025). Epigenetic Regulation of Neuroinflammation in Dementia of Alzheimer’s Disease and Other Forms of Dementias. EC Clinical and Medical Case Reports, 8.9:01-14. DOI: 10.31080/ECCMC.2025.08.01047.

  5. Singh AS and Chanu MT. (2025). Profiling early growth response (Egr-1) gene expression in the honeybee brain during foraging. World Journal of Advanced Research and Reviews, 28:964-973. DOI: https://doi.org/10.30574/wjarr.2025.28.3.4159.

  6. Chanu MT, Singh AS. (2024). Different types of Cancer treatment, its advancement, benefits, and side effects. World Journal of Advanced Research and Reviews, 24:571–580. DOI: 10.30574/wjarr.2024.24.1.2994.

  7. Chanu MT, Singh AS. (2022). Medicinal plant derived drugs and their treatment for human diseases like cancer: A review. World Journal of Advanced Research and Reviews, 16:580–585. DOI: 10.30574/wjarr.2022.16.2.1128.

  8. Singh AS, Machathoibi TC. (2022). Potential role of immediate early genes Egr-1, Hr-38 and Kakusei in the foraging behaviour and learning of in honeybees. World Journal of Advanced Research and Reviews, 16:458–465. DOI: 10.30574/wjarr.2022.16.2.1169.

  9. Machathoibi TC, Singh AS (2022). Cancer disease and its’ understanding from the ancient knowledge to the modern concept. World Journal of Advanced Research and Reviews, 15 169–176. DOI: https://doi.org/10.30574/wjarr.2022.15.2.0809.

  10. Machathoibi TC, Singh LS (2022). Croton caudatus Geiseler Induces Differentiation of the Acute Myeloid Leukemia cell lines. Biorexiv. https://doi.org/10.1101 /2022.06.30.498361.

  11. Sharma AL, Meitei PM, Machathoibi TC, Singh NT, Singh TR and Singh LS (2022). Ovarian cancer G protein-coupled receptor1 inhibits A549 cells migration through casein kinase 2α intronless gene and neutral endopeptidase BMC Cancer.

  12. Singh AS and Machathoibi TC (2021). Alzheimer’s disease and Aβ pathways World Journal of Advanced Research and Reviews. 12:542–544. DOI: https://doi.org/10.30574 /wjarr.2021.12.3.0740.

  13. Singh AS and Machathoibi TC (2021). A method to study honeybee foraging regulatory molecules at different times during foraging. Frontiers of Insect Science.doi: 10.3389/finsc.2021.723297

  14. Singh AS and Machathoibi TC (2021). The Natural Habitats, Biodiversity Hotspots, Local Indigenous Cultures And Tourism Attraction in The North Eastern States Of India. British Journal of Biomedical Research. DOI: https://doi.org/10.24942/bjbmr.2021.824.

  15. Singh AS and Machathoibi TC (2021). Honeybee Products: Honey And Royal Jelly and Their Nutritional And Medicinal Values to Humans. British Journal of Biomedical Research. DOI: https://doi.org/10.24942/bjbmr.2021.815.

  16. Singh AR, Singh SA, Singh TD, Singh NT, Machathoibi TC, Singh OM, Singh LS (2021). Bioassay-guided isolation of 2-[p-(2-Carboxyhydrazino)phenoxy]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol from Oroxylum indicum and investigation of its molecular mechanism action of apoptosis induction. Pharmacuticals MDPI.

  17. Machathoibi TC, Singh AR, Singh TD, Singh TR, Damayenti. M, Singh LS (2020). Croton caudatus Geisel Induces Apoptosis in Prostate Cancer Cell Lines. Proteus Journal Vol. I Issue 11. ISSN/eISSN: 0889-6348.

  18. Singh AS, Machathoibi TC, Cappelletti P, Feligioni M (2020). “Immediate early gene Kakusei potentially plays a role in the daily foraging of honeybees.” PLoS One. Doi: 10.1371/journal.pone.0222256.

  19. Devi MS, Singh TB, Singh AR, Singh LS, Ansari MA, Singh TS, Machathoibi TC (2017). Determination of Organophosphorus, Carbamate and Synthetic Pyrethroids Residues in Fish of Loktak Lake (a Ramsar Site) by Using High Performance Liquid Chromatography.

  20. Sharma AL, Singh TR, Machathoibi TC, Singh SD, Devi KR and Singh LS (2014). Genetic study of vpu variant among the HIV-1 infected intravenous drug users of Manipur predicts highly pathogenic virus. IIJSR. 1(no.2):106-12.

 

Book Chapter

  • Development of Non-cytotoxic Anticancer Therapeutic Drugs from Medicinal Plants Asem Robinson, T. Chanu Machathoibi, Salam Dayananda Singh and Lisam Shanjukumar Singh* CURRENT TOPICS IN REDOX BIOLOGY (G.J. Sharma and R.N. Sharan, Eds. McGraw Hill Education (India), New Delhi; 2014)

 

Patents

  • Singh LS, Machathoibi TC, Singh AR, Singh D (2021). Composition for the prevention or treatment of mastitis. Patent number 202131039468.

 

M.Sc Project Guidance

  • Mangsatabam Memthoilata: Antimicrobial property of Zingiber officinale against some microbial stain. (2009-2012)

  • Ningombam Sangita: Studies of few medicinal plants of Manipur for anti-cancer activity (2013-2015)

  • Avei Justin: Purification of Stevioside from Stevia rebaudiana (Bertoni). (2014-2016)

  • Ahanthem Soshanta: Phylogenetic analysis of sars-cov-2 and mutation of spike protein in orf2b. (2018-2020)

 

Invited Lecture

  • Cancer and Genomics. “National Symposium on Recent Advances in Biotechnology”. Organized by DBT-Institutional Biotech Hub, sponsored by Department of Biotechnology, Ministry of Sc. & Tech., GOI. Department of Zoology, D.M. College of Science. Imphal-795001, Manipur (2011).

  • Seminar on Mass Spectroscopy BY Agilent Technology in Imphal, Manipur, India. 2016

 

Poster Presentation

  • Novel lncRNAs MSTRG.479558.1 and MSTRG.582898.5 regulate myeloid dendritic cell differentiation and innate immune function. Annual non-coding RNA Symposium, University of Chicago, Illinois, USA. (2025)

  • A potential role of non-coding immediate early gene kakusei in honeybee foraging and learning. Annual microRNA symposium, University of Chicago, Illinois, USA. (2022)

  • Immediate early genes play potential role in honeybee foraging and learning. Annual microRNA symposium, University of Chicago, Illinois, USA. (2022)

  • Role of immediate early genes in honeybee foraging and learning. 4th ASNI School, The Ohio State University West Lane Avenue Columbus, Ohio, USA. (2022).

 

Conference and Symposium Attended:

  • National Seminar on Redox Biology Decoding MicroRNA Mysteries in Health and Disease. (Two-days virtual symposium) University of Illinois Chicago, College of Dentistry. (2021).

  • International Conference on Molecular Signalling: Recent Trends in Biosciences. Department of Zoology, North-Eastern Hill University, Shillong, Meghalaya, India. (2015)

  • Current Topics in Redox Biology: organized by Centre of Advanced Study in Life Sciences, Manipur University, Imphal-West, Manipur, India. (2013)

 

Academic editorial roles:

  • ACCScience Publishing, Innovative medicine and OMICS

 

Training programme attended:

  • Two Days training on Practical Approaches for Conservation of Bioresources in North-East India held on 25th and 26th April 2005. Institute of Bioresources and Sustainable Development. Manipur. Department of Biotechnology, India.

  • Training Program on Confocal Laser Scanning Microscopy and Its applications. 27th to 29th June, 2016. Guwahati Biotech Park, IIT Guwahati, Assam, India.

 

Subject expert:

  • Selection Committee for the appointment of one Substitute Teacher in Biotechnology under Faculty Development Programme of the UGC. (2011)

  • Selection of one JRF for project entitled “Genomic Sequencing of HIV-1 variant in AIDS pandemic of Manipur “for a DBT funded project. (2011)

  • Selection of one PA for the project entitled “Proteomic Analysis of Mechanism of a New Metastasis Suppressor Gene” funded by UGC. (2011)

  • Selection of one PA for the CSIR funded project. (2011)

 

Workshop Attended:

  • Capacity building in grant writing skills and effective management of Intellectual Property Rights (IPR) in Biotechnology by Universities and research institutions in North East Region” at Department of Biotechnology, Manipur University, Imphal Sponsors, Department of Biotechnology, Government of India, Organized by Biotech Consortium India Limited (BCIL), New Delhi. (2017)

  • Hand on training programme on Conservations of Biodiversity of North-Eastern India held on IBSD, Imphal, and Manipur. Department of Biotechnology India. (2005).

 

Orientation Programme and Refresher Course attended:

  • Winter School: Advancements in Medical Sciences and Question of Ethics. UGC- Sponsored. UGC-Academic Staff College. (2017)

  • Orientation Programme “Knowledge and Development”. UGC-Sponsored Orientation Programme. UGC- Academic Staff College, Manipur University, Canchipur, India. (2011)

  • Member of the Departmental Organizing Committee of the “National workshop and Hand-on training programme in Molecular Techniques in Biotechnology.” (2012)

  • Refresher Course in Biochemistry. UGC-Sponsored Refresher Course. (2012)

 

Academic administrative roles:

  • Member for Inspection of Don Bosco College, Maram, Manipur for Opening of Biotechnology as elective subject from the academic session. (2016-2017)

  • Member of Drafting Committee for B. Sc Biotechnology Syllabus for NEP. (2022)

  • Member for a Committee to find out a proper way for functioning of the Central Instrumentation Centre. (2017)

  • Member of School Board of Studies, Life Sciences.

  • Member of Selection Committee for selection of two, Junior Research Fellow for IBSD-funded Project entitled “Bioactivity guided isolation and purification of neuroprotective molecules from Isodon ternifolius and Tinospora cordifolia.”May (2017)

  • Member for Drafting Syllabus and Ordinance for Two Years M.Sc. Biotechnology Course. (2010)

  • Member for Committee for preparing question models for B. Sc Biotechnology Semester Examination. (2010)

  • Member for Drafting of Syllabus and Ordinance for 5 years Integrated Biotechnology. (2009)

  • Member for Departmental Purchase Committee, Departmental School Board of Studies. (2009)

 

 

 

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