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Dr. Reena Haobam

Designation: Associate Professor

Specialization: Biochemistry, Neuroscience, Stem cell Biology

Contact:

Email: reena_haobam [AT] rediffmail.com, reena_haobam [AT] manipuruniv.ac.in

M.Sc., Ph.D.

Website: http://manipuruniv.ac.in/faculty/72

Name of the faculty: DR. REENA HAOBAM

Designation: Associate Professor, Department of Biotechnology, Manipur University

E-mail: reena_haobam [AT] rediffmail.com, reena_haobam [AT] manipuruniv.ac.in

Specialization: Biochemistry, Neuroscience, Stem cell Biology

Area of research:

Genomics of drug dependence, Genotyping of MDR-TB and drug metabolism genes, Identification and purification of neuro-protective molecules from plant sources.

Research publications:

  1. Koijam AS, Hijam AC, Singh AS, Jaiswal P, Mukhopadhyay K, Rajamma U & Haobam R. “Association of Dopamine Transporter Gene with Heroin Dependence in an Indian Subpopulation from Manipur”, J of Molecular Neuroscience, published online 18 June 2020, https://doi.org/10.1007/s12031-020-01633-5

 

  1. Koijam AS, Chakraborty B, Mukhopadhyay K, Rajamma U & Haobam R. “A single nucleotide polymorphism in OPRM1(rs483481) and risk for heroin use disorder”, Journal of Addictive Diseases, 38:2, 214-222, 2020.

 

  1. Singh KA and Haobam R. “Association of DRD2 gene polymorphism with heroin dependence.” Heroin Addict Relat Clin Probl, 21(4): 5-14, 2019.

 

  1. Haobam R, Tripathy D, Kaidery NA and Mohanakumar KP. “Embryonic stem cell derived neuron transplantation recovery in models of parkinsonism in relation to the severity of the disorder in rats.” Rejuvenation Res. 18(2): 173-184, 2015. doi: 10.1089/rej.2014.1626.

 

  1. Tripathy D, Haobam R, Nair R and Mohanakumar KP. “Engraftment of mouse embryonic stem cells differentiated by default leads to neuroprotection, behaviour revival and astrogliosis in parkinsonian rats.” PlosOne, 8 (9), e72501, 2013. doi: 10.1371/journal.pone.0072501. eCollection 2013.

 

  1. Karuppagounder SS, Madathil SK, Pandey M, Haobam R, Rajamma U and Mohanakumar KP. Quercetin up-regulates mitochondrial complex-I activity to protect against programmed cell death in rotenone model of Parkinson's disease in rats. Neuroscience. 236:136-48, 2013. doi: 10.1016/j.neuroscience.2013.

 

  1. Madathil KS, Karuppagounder SS, Haobam R, Varghese M, Rajamma U and Mohanakumar KP. Nitric oxide synthase inhibitors protect against rotenone-induced, oxidative stress mediated parkinsonism in rats. Neurochem Int, 62(5): 674-83, 2013. doi: 10.1016/j.neuint.2013.

 

  1. Haobam R, Sindhu KM, Chandra G, Mohanakumar KP. Swim-test as a function of motor impairment in MPTP model of Parkinson’s disease: a comparative study with two mouse strains. Behav Brain Res, 163(2), 159-167, 2005. PMID 15941598.


 

  1. Mehta H, Haobam R, Usha R, Mohanakumar KP. Evidence for the involvement of central serotoninergic mechanisms in cholinergic tremor induced by tacrine in Balb/c mice. Behav Brain Res, 163(2), 227-236, 2005. PMID 15990178.

 

 

Abstracts published:

 

  1. D Tripathy, R Haobam, KP Mohanakumar, Generation of dopaminergic neurons from mouse ESC and post transplantation recovery in rotenone-induced experimental parkinsonism J Neurochem, 125. 196, 2013.

 

  1. R Haobam, KM Sindhu, KS Saravanan, M Varghese, R Usha, KP Mohanakumar, Nitric oxide, a mediator in rotenone-induced parkinsonism in rats, J Neurochem, 98. 115, 2006.

 

Books chapters published:

  1. Chanu HA, Singh KA, Devi NP, Haobam R, “Antimicrobial and Antioxidant Activities of the Crude Extracts of Goniothalamus sesquipedalis (Wall.) Hook. F.&Thomson” in Medicinal Plants- Exploration, Evaluation and Utilization: 1, 116-126, 2019, Pointer Publishers, Jaipur, Rajasthan, India.

  2. Singh KA and Haobam R, “PCR, RFLP and Gel Electrophoresis as Genotyping Tools for Studying SNPs, MicroINDELS and VNTRs” in Trends in Experimental Biology: 2, 95-111, 2016, Excel India Publishers, New Delhi, India.

  3. Haobam R and Mohanakumar KP, ‘Mouse ES cell culture and differentiation to neuronal cells’, A handbook of Neurochemical Techniques for neuroscientist, 85-88, 2007.

  4. Haobam R, Debasmita T and Mohanakumar KP. ‘Differentiation and characterization of mouse embryonic stem cell derived neuronal cells’, A handbook of Neurobiological Techniques, 9-14, 2008.

Patents:

  • Mohanakumar KP, Chandra G, Haobam R and Selly ML; “Treatment of Brain disorders”, United States Patent Application Publications, Pub. No.: US 2009/0143388 A1, June 4, 2009.

 


 

Awards and honours:

  • University Gold Medal, M.Sc. (Biochemistry) 2002.

  • University Gold Medal, B.Ed. 2003

  • ICMR-JRF, June 2003

  • UGC-JRF, June 2003

  • DBT-travel award, 2006

Projects:

Sl. No.

Title

Duration

Funding Source

  1.  

Analysis of OPRM1 and DAT1 as possible candidate genes for drug addiction: A population-based association study in the Indian population from Manipur”

2012-15

DBT

  1.  

Bioactivity guided isolation and purification of neuroprotective molecules from Isodon ternifolius and Tinospora cordifolia.

 

2017-19

IBSD-partnership program

  1.  

Evolution and transmission of drug-resistance tuberculosis in Agartala, Kohima and Imphal population”

2018-21

DBT

  1.  

DNA methylation analysis of OPRM1 and DAT1 genes in drug dependent population of Manipur-a population based association study”

2019-2022

ICMR


 

Collaborating Institutes:

  • International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi

  • Jawaharlal Nehru Institute of Medical Sciences (JNIMS), Imphal

  • Naga Hospital Authority, Kohima

  • Agartala Government Medical College, Agartala

  • Institute of Bioresources and Sustainable Development (IBSD), Imphal

  • Manovikas Kendra Rehabilitation & Research Institute for the Handicapped (MRIH), Kolkata

 

Membership of Scientific Societies:

  • International Society of Neurochemistry (ISN)

  • Society of Biological Chemists, India (SBC)

  • Indian Science Congress Association, India (ISCA)

  • Environmental mutagen society of India (EMSI)

 

Ph.D. Scholars:

  1. Koijam Arunkumar Singh (CSIR -NET)- Submitted Thesis

 

  1. Hijam Aruna Chanu (CSIR-NET)

 

  1. Heikrujam Nilkanta Meitei (SLET-NE region, CSIR-NET)

 

  1. Anupama Pandey (Project SRF)

 

  1. Nongthombam Pooja Devi (CSIR-NET)

 

 

 

Project Fellows:

 

  • Tongbram Yaiphabi Chanu (Project-JRF, GATE qualified)