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Manipur Univ


Dr Lisam Shanjukumar Singh

Designation: Professor & Head

Specialization: Cancer Biology, Molecular Biology & HIV

Contact:

Email: shanju.lisam [AT] manipuruniv.ac.in

Msc, Ph.D.

Website: http://manipuruniv.ac.in/faculty/70

Faculty Details Faculty List

Publications:

  1. Diagnostic Accuracy of Conventional Cell Blocks Along with p16INK4 and Ki67 Biomarkers as Triage Tests in Resource-poor Organized Cervical Cancer Screening Programs. Desai F, Lisam Shanjukumar Singh, Majachunglu G, Kamei H. Asian Pac J Cancer Prev. 2019 Mar 26;20(3):917-923. PMID: 30912415

  2. Spindlin docking protein (SPIN.DOC) interaction with SPIN1 (a histone code reader) regulates Wnt signaling. Devi MS, Meiguilungpou R, Sharma AL, Anjali C, Devi KM, Singh LS, Singh TR. Biochem Biophys Res Commun. 2019 Apr 9;511(3):498-503. oi: 10.1016/j.bbrc.2019.02.096. Epub 2019 Feb 23. PMID: 30803761

  3. Antiretroviral resistance, genotypic characterization and origin of Human Immunodeficiency Virus among the infected wives of Intravenous drug users in Manipur. Adhikarimayum Lakhikumar Sharma, Thiyam Ramsing Singh & Lisam Shanjukumar Singh. 2018 (Oct)doi: 10.1038/s41598-018-33636-z, Scientific Report.

  4. Molecular epidemiology of HIV-1 among the HIV infected people of Manipur, Northeastern India: Emergence of unique recombinant forms. A. Lakhikumar Sharma, Th. Ramsing Singh, Kh. Ranjana Devi, L. Shanjukumar Singh. J. Med Virol, 2016 Nov., 21, 9999: 1–11, PubMed ID 27869320

  5. Retrospective Evaluation of Risk Factors and Immunohistochemical Findings for Pre Neoplasticand Neoplastic lesions of Upper Urinary Tract in Patients with Chronic Nephrolithiasis. Desai FS, Nongthombam J, Singh LS. Asian Pac J Cancer Prev. 2015;16(18):8293-8.

  6. Anticancer properties and enhancement of therapeutic potential of cisplatin by leaf extract of Zanthoxylum armatum DC. Singh TD, Meitei HT, Sharma AL, Robinson A, Singh LS, Singh TR. Biol Res. 2015 Aug 20;48:46. doi: 10.1186/s40659-015-0037-4. PubMed PMID: 26290043.

  7. Evaluation of Risk Factors for Nasopharyngeal Carcinoma in a High-risk Area of India, the Northeastern Region. Deepak Singh Lourembam, Asem Robinson Singh, T. Dhaneshor Sharma, Th Sudheeranjan Singh, Thiyam Ramsing Singh, L. Shanjukumar Singh. Asian Pac J Cancer Prev, 16 (12), 4927-4935, 2015.

  8. Genetic Study of vpu variants among the HIV-1 Infected Intravenous Drug Users of Manipur Predicts Highly Pathohenic virus. A Lakhikumar Sharma, Thiyam Ramsing Singh, Takhellambam Chanu Machathoibi1, Salam Dayananda Singh, Kh. Ranjana Devi, L. Shanjukumar Singh. International Interdisciplinary Journal of Scientific Research (IIJSR) Vol. 1 No. 2 November, 2014

  9. Analysis of Viral Protein U variant at Amino Acid Position 61 among the Heterosexually transmitted HIV-1 Patients of Manipur. A. Lakhikumar Sharma, Th. Ramsing Singh, Kh. Ranjana Devi, L. Shanjukumar Singh. International Journal of Current Research and Review (IJCRR) 2015; 7(5):24-29.

  10. Dengue: Infection, diagnosis and vaccine production. Yengkhom Sangeeta Devi and L. Shanjukumar Singh. INT J CURR SCI 2014, E 81-97 13

  11. Mutational analysis of HIV-1 viral protein U at Ser52 and Ser56 among the HIV-1 infected patients of Manipur. A Lakhikumar Sharma, Thiyam Ramsing Singh, Kh. Ranjana Devi, Lisam Shanjukumar Singh. HIV & AIDS Review (2015), http:// dx.doi.org/10.1016/j.hivar.2015.07.002.

  12. Prevalence of Drug Resistance Associated Mutations Among the Anti-Retroviral Therapy Exposed HIV-1 Infected Individuals in Manipur, Northeast India. Lakhikumar Sharma A, Ramsing Singh T, Ranjana Devi K, Shanjukumar Singh L. Curr HIV Res. 2016;14(4):360-70.

  13. Evaluation of Urological Cancers Characteristics in Manipur-Are they different from other Regions of India? Desai Fanney, Nongthomabm Jitendra, Lisam Shanjukumar Singh. Int J Curr Sci. 18:E37-44 (2015)

  14. Role of OGR1 in myeloid-derived cells in prostate cancer. Yan, L. Shanjukumar Singh, Zhang, L., and Xu, Y. Oncogene 1 – 8, 2012

  15. Abnormalities in osteoclastogenesis and decreased tumorigenesis in mice deficient for ovarian cancer G protein-coupled receptor 1 (OGR1). Li H, Wang D, L. Shanjukumar Singh, Berk M, Tan H, Zhao Z, Steinmetz R, Kirmani K, Wei G, Xu Y. PLoS One. 2009 May 28;4(5)

  16. Dengue: Infection, diagnosis and vaccine production. Yengkhom Sangeeta Devi and L. Shanjukumar Singh. E 81-97 INT J CURR SCI 2014, 13

  17. Development of Non-Cytotoxic Anticancer Therapeutic Drugs from Medicinal Plants. Robinson A, Machathoibi TC, Singh S Dayananda, L. Shanjukumar Singh. CURRENT TOPICS IN REDOX BIOLOGY, (Eds: GJ Sharma & RN Sharan): McGraw Hill Education, 2014

  18. Leaf extract of Zanthoxylum armatum induced apoptosis in human cervical cell line by activating ERK. Th. Davis Singh, A. Lakhikumar Sharma, A. Robinson Singh, L. Shanjukumar Singh, Th.Ramsing Singh; Current topics in redox biology (Eds, GJ Sharma & RN Sharan). McGraw Hill Education, 2014, pp 178-190

  19. Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer. L. Shanjukumar Singh, Berk M, Oates R, Zhao Z, Tan H, Jiang Y, Zhou A, Kirmani K, Steinmetz R, Lindner D, Xu Y. J Natl Cancer Inst. 2007 Sep 5;99(17):1313-27.

  20. Novel lipid Signaling pathways in ovarian cancer cells (Review) Xu. Y, Sengupta. S,. L. Shanjukumar Singh and Rosemary, S. Cellscience Review 2006 Vol. 3 (1)

  21. Homo- and hetero-dimerization of LPA/S1P receptors, OGR1 and GPR4. Zaslavsky A, L. Shanjukumar Singh, Tan H, Ding H, Liang Z, Xu Y. Biochim Biophys Acta.2006 Oct; 1761(10):1200-12.

  22. Lysophosphatidic acid is constitutively produced by human peritoneal mesothelial cells and enhances adhesion, migration, and invasion of ovarian cancer cells. Ren J, Xiao YJ, L. Shanjukumar Singh, Zhao X, Zhao Z, Feng L, Rose TM, Prestwich GD, Xu Y. Cancer Res. 2006 Mar 15;66(6):3006-14.

  23. KiSS1 suppresses metastasis in human ovarian cancer via inhibition of protein kinase C alpha. Jiang Y, Berk M, L. Shanjukumar Singh, Tan H, Yin L, Powell CT, Xu Y ClinExp Metastasis. 2005;22(5):369-76.

  24. The contribution of amino acid region ASP695-TYR698 of factor V to pro-cofactor activation and factor Va function. Beck DO, Bukys MA, L. Shanjukumar Singh, Szabo KA, Kalafatis M. J Biol Chem. 2004 Jan 23;279(4):3084-95.

  25. Amino acids Glu323, Tyr324, Glu330, and Val331 of factor Va heavy chain are essential for expression of cofactor activity. L. Shanjukumar Singh, Bukys MA, Beck DO, Kalafatis M. J Biol Chem. 2003 Jul 25;278(30):28335-45.

  26. Sequencing of full-length cDNA encoding the alpha and beta subunits of human casein kinase II from human platelets and megakaryocytic cells. Expression of the casein kinase IIalpha intronless gene in a megakaryocytic cell line. L. Shanjukumar Singh, Kalafatis M. Biochemistry. 2002 Jul 16;41(28):8935-40.

  27. Purification and characterization of intestinal adenosine deaminase from mice. L. Shanjukumar Singh, Sharma R. Mol Cell Biochem. 2000 Jan;204(1-2):127-34.

  28. Alloxan diabetes regulates adenosine deaminase activity in mice: tissue- and age- specific correlation. L. Shanjukumar Singh, Sharma R. Biochem Mol Biol Int. 1998 Sep;46(1):55-61.

  29. Developmental and hormonal regulation of intestinal adenosine deaminase in mice. L. Shanjukumar Singh and Sharma, R. J Biochem. Mol.Bio. & Biophy. 1997. 1(2), 125-132.

  30. Developmental expression and corticosterone inhibition of adenosine deaminase activity in different tissues of mice. L. Shanjukumar Singh and Sharma R. Mech Ageing Dev. 1995 May 12;80(2):85-92. PubMed PMID: 7564566.

 

UNDER PREPARATION/COMMUNICATED:

  1. Role of protein kinase 2 in Phorbol 12-Myristate 13-Acetate (PMA) induces macrophage differentiation. Thuirei Jacob Ningshen, Thiyam Ramsing Singh, Lisam Shanjukumar Singh

  2. Molecular mechanism of OGR1 in cancer metastasis. A Lakhikumar Sharma, Thiyam Ramsing Singh, Lisam Shanjukumar Singh

    PATENT: R20182017098/201821019776 (Applied)

AWARD RECEIVED :

  1. Achievement for Excellence in Cancer Research, Indiana University Cancer Center, Indiana, USA (2006)

  2. Innovation award for “Development of a method for the inhibition of metastasis” The Cleveland Clinic, USA (2004)

Ph. D. SCHOLARS-Degree Awarded

  1. Dr. A. Lakhikumar Sharma, (Current Address: Temple University, Philadelphia, USA)

  2. Dr. Asem Robinson Singh, (Current Address: Collage of Horticulture, Community Science & Biotechnology, Henbung, Manipur)

  3. Dr. Deepak Lourembam (Co-supervisor)

  4. Dr. Thangjam Davis (Co-supervisor)

Ph.D SCHOLARS: On-going

  1. Ms. T. Chanu Machathoibi, Asst Professor, Manipur University

  2. Dr Fanny Sharadkumar Desaai, MBBS, MD (DST Woman Scientist)

  3. Mr. N. Tarundas Singh

  4. Mr. Puyam Milan Meitei

  5. Ms. Anoubam Sujita Devi

  6. Mr. Salam Asbin

  7. Ms. Ahenthem Sapana Devi

  8. Ms. Shamjetshabam Nandibala

  9. Ms. Minhaz Korimayum

 

RESEARCH ASSOCIATE:

  1. Dr. Thuirei Jacob Ningshen (DBT-RA)- completed (Current Address: Modern college, Manipur)

  2. Dr. A. Lakhikumar Sharma, (DST-RA)- completed (Current Address: Temple University, Philadelphia, USA)

  3. Dr. Pamchui Muiwo (DST-RA)

 

M.SC. STUDENTS PROJECT WORK:

  1. Iebmhanbi Konthoujam, Vijayaraje institute of Sciences & Management, Turari, Gwalior

  2. Brahmacharimayum Jamuna Devi Vijayaraje institute of Sciences & Management, Turari, Gwalior

  3. Wayembam Premika Devi, Nandha Arts & Science college, Erode, Tamil Nadu

  4. Laishram Sahela Devi, Nandha Arts & Science college, Erode, Tamil Nadu

  5. Sharifun Shahnaj, Department of Biotechnology, Manipur University

  6. Konthoujam Jeken Singh, Doon (PG) Paramedical College & Hospital, Dehradun

  7. Khumanthem Nirupama Devi, Nandha Arts & Science college, Erode, Tamil Nadu

  8. Sophia Wahengbam, Amity University, Utta Pradesh

 

RESEARCH PROJECT:

  1. Completed project : 11 major projects since 2011

  2. On-going: 2 major projects

 

COLLABORATING INSTITUTES:

  1. Regional Institute of Medical Sciences (RIMS), Imphal

  2. Jawaharlal Nehru Institute of Medical Sciences (JNIMS), Imphal

  3. Indian Institute of Sciences, Bangalore

  4. Narayana Hrudayalaya Foundation, Bangalore (past)

 

OTHER ACADEMIC ACTIVITIES:

  1. Member of Technical Expert Committee - DBT-NER - Govt of India

  2. Member of Expert Committee, YS (Life Science) DST-SERB, Govt of India

  3. Convener: Institutional Human Ethical Committee, Manipur University

  4. Member: Institution Human Ethic Committee, NIT, Manipur

  5. Convener: Institutional Biosafety Committee, Manipur University

  6. Nodal Academician of Manipur State: Guwahati Biotech Park, Guwahati

  7. General Secretary, Manipur University Teachers’ Association, Manipur University