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Dr Okram Mukherjee Singh

Designation: Professor

Specialization: Organic Chemistry

Contact: +91-9402882759

Email: ok_mukherjee [AT] yahoo.co.in, omsingh [AT] manipuruniv.ac.in

M.Sc. Ph.D.

Website: http://manipuruniv.ac.in/faculty/100

  • Name: Dr. Okram Mukherjee Singh

  • Designation: Professor and HOD

  • Department: Chemistry

  • University: Manipur University, Canchipur-795003, Manipur

  • Phone: 9402882759

  • DOB: 01-02-1965

  • E-mail: (a) ok_mukherjee [AT] yahoo.co.in, (b) omsingh [AT] manipuruniv.ac.in

  • Area of specialization: Organic Chemistry

  • Current interest: Synthesis of bioactive heterocycles and natural products

  • Qualification: M.Sc. Ph.D.

  • Academic Qualification (Graduate onwards)











NEHU, Shillong






NEHU, Shillong



Ph. D.


Organic Chemistry

NEHU, Shillong



  • Teaching Profile






Assistant Professor




Associate Professor









1. Summer Research Fellowship award by Indian Academy of Sciences, Bangalore to work for 2 months in University of Hyderabad 1997.






1. University of Utah, USA in the group of Prof. Peter J. Stang, 2005-2006 (For conducting advanced research in self-assembly and supra-molecular chemistry).

2. University of Manchester, UK in the group of Prof. E. J. Thomas, 2012 (For conducting advanced research on the synthesis of natural products).

3. DST international travel grant award for visiting Vienna, Austria to participate in the Tetrahedron Symposium in 2013.

4. DST international travel grant award for visiting University Regensbertg, Germany to participate in the 17th International Society of Heterocyclic Chemistry (ISHC) Congress in 2017.



  1. L. M. Devi, T. P. Singh, O. M. Singh. Recent advances in C-C/heteroatom bond forming and annulation reactions of β-ketodithioesters. Current Organic Synthesis. 2021, 18, 826- 843

  2. R.R. Singh, T.J. Devi, T.J. Devi, O.M. Singh. Choline based deep eutectic solvent mediated Friedlander annulation: A sustainable and regiospecific approach to polysubstituted quinoline. Current Research in Green and Sustainable Chemistry. 2022, 5, 100272.

  3. R.R. Singh, T.P. Singh, T.L. Devi, T.J. Devi, O.M. Singh. Synthesis of 2, 4-disubstituted quinazolines promoted by deep eutectic solvent. Current Research in Green and Sustainable Chemistry. 2021, 4, 100130.

  4. L. V. Chanu, O. M. SinghRecent progress in silica-supported heterogeneous catalyzed reactions for the synthesis of azoles and related five-membered ring heterocyclesJournal of Heterocyclic Chemistry. 2021, 58, 2207-2225.

  5. T. J. Devi, T. P. Singh, R. R. Singh, K. G. Sharma, O. M. Singh. Synthesis of Tri-indolylmethane Derivatives Using a Deep Eutectic Solvent. Russian Journal of Organic Chemistry. 2021, 57, 255–264.

  6. R. R. Singh, T. P. Singh, N.P. Singh, S. S. Naorem, O. M. SinghSynthesis of Green/Blue Light Emitting Quinolines by Aza-DA Reaction Using InCl3 CatalystJournal of Fluorescence.  2021, 31, 247–257.

  7. T. J. Devi, T. P. Singh, R. R. Singh, E. H. Singh, O. M. Sing, Deep Eutectic Solvent Promoted Regioselective Synthesis of Densely Functionalized Mono and Bisindolylalkenes from β?Ketodithioester, ChemistrySelect. 20205, 13351-13357.

  8. I. H. Chanu, L. M. Devi, T. P. Singh, R.R. Singh, S. J. Singh, O. M. Singh?-Ketodithioesters as Versatile Building Blocks for the Diversity Oriented Synthesis of Thioamides, α-Allylated-Thioesters and KetoamidesChemistrySelect. 20205,7447 –7451

  9. T. J. Devi, T. P. Singh, O. M. SinghThe one-pot four-component eco-friendly synthesis of spirooxindoles in deep eutectic solvent, Journal of Chemical Sciences2020132:28.

  10. L. V. Chanu, K. Nongalleima, S. P. Singh, W. K. Chanu, C. B. Singh, O. M. SinghSynthesis, anti-inflammatory evaluation and in silico studies of naphtho[1,2-e][1,3]oxazine derivatives as potential non-steroidal anti-inflammatory agents, Medicinal Chemistry Research202029, 229–242.

  11. T. P. Singh, T. J. Devi, N. P. Singh, O. M. SinghGFP Chromophores from L?Phenylalanine: Synthesis, Photophysical and Thermal Properties, ChemistrySelect20183, 6596-6600.

  12. L. V. Chanu, T. P. Singh, L. R. Devi, O. M. Singh, Synthesis of bioactive heterocycles using reusable heterogeneous catalyst HClO4–SiO2 under solvent-free conditions, Green Chemistry Letters and Reviews201811, 352-360.

  13. T. P. Singh, O. M. Singh. Recent progress in biological activities of indole and indole alkaloids, Mini Reviews in Medicinal Chemistry. 2018189-25.

  14. I. H. Chanu, L. R. Devi, N. Khumanthem, N. I. Singh, D. Kumar, O. M. Singh. Synthesis of functionalized benzo[f]2H-chromenes and evaluation of their antimicrobial activitiesRussian Journal of Bioorganic Chemistry. 2017, 43, 177–185.

  15. T. P. Singh, O. M. Singh. One pot synthesis of 1-substituted tetrahydro-β-carbolines by Bischler–Napieralski cyclization, Journal of Chemical Sciences2016128, 565-572.

  16. N. S. Devi, S. J. Singh, K. Mahiya, L. R. Devi, O. M. Singh, H. Choi, S.-G. Lee. Novel Synthesis of Tryptamine Derived 4?Hydroxy?4?arylthiazolidine?2?thiones and 4?Arylthiazole?2(3H)?thiones by Multicomponent Reactions, Bulletin of the Korean Chemical Society201637, 1472-1477.

  17. V. Reddy P O,  M. P. Tantak,  R. Valdez,   R. P. SinghO. M. SinghR. SadanaD. Kumar.   Synthesis and biological evaluation of novel carbazolyl glyoxamides as anticancer and antibacterial agentsRSC Advance. 20166, 9379-9386.

  18. L. R. Devi, L. V. Chanu, I. H. Chanu, O. M. SinghFacile Synthesis of Octahydroxanthenes by One-Pot Reaction under Solvent-Free ConditionAsian Journal of Chemistry201628,1528-1530.

  19. O. Z. Devi, K. S. Rao, A. Bidalia, R. Wangkheirakpam, O. M. Singh, GC-MS analysis of phytocomponents and antifungal activities of Zanthoxylum acanthopodium DC. collected from Manipur, IndiaEuropean Journal of Medicinal Plants, 2015, 10, 1-9.

  20. L. R. Devi, L. V. Chanu, H. Choi, D. Lee, O. M. Singh, S.-G. Lee. Silica–ZnCl2: An Efficient and Reusable Solid Catalyst for One Pot Synthesis of 5-Methyl Mercaptothiocarbonyl-4-aryl-3-dihydropyrimidin-2(1H)-ones Under Solvent-Free Conditions, Bulletin of the Korean Chemical Society201536, 2915–2919

  21. O. M. Singh, L. R. Devi, K. B. Lim, S.-G. Lee. Regioselective Synthesis of Polyaza Pyrimidines and Polyaza Pyrazoles under One?Pot Multicomponent Reaction Conditions, Journal of Heterocyclic Chemistry. 201451, 1340-1344.

  22. T. P. Singh, R. Khan, Y. R. Noh, S.-G. Lee, O. M. Singh. Indium (III) chloride mediated michael addition of indoles to ketene s, s-acetals: synthesis of bis-and tris-indolylketones, Bulletin of Korean Chemical Society. 2014, 35, 2950-2954.

  23. K. A. Devi, L. G. Chanu, I. H. Chanu, O. M. Singh. One-pot synthesis of 1H-naphtho [2, 1-b] pyran derivatives under solvent-free conditions, Letters in Organic Chemistry201411, 743-747.

  24. L. G. Chanu, T. P. Singh, Y. J. Jang, Y.-J. Yoon, S.-G. Lee, O. M. Singh. Synthesis of Imidazo [1, 2-a] pyridines and Pyrido [1, 2-a] pyrimidines in Water and their SNAr Cyclizations, Bulletin of Korean Chemical Society.201435, 994-1000.

  25. T. P. Singh, S. Bhattacharya, O. M. Singh. Indium/TFA-catalyzed synthesis of tetracyclic [6, 5, 5, 6] indole ring, via a tandem cycloannulation of β-oxodithioester with tryptamineOrganic Letters201315, 1974-1977.

  26. N. S. Devi, S. J. Singh, L. R. Devi, O. M. Singh. Facile route to highly functionalized 2H-chromene-2-thiones via ring annulations of β-oxodithioesters with phenols catalyzed by AlClunder solvent-free Tetrahedron Letters …,. 201354, 183.

  27. N. S. Devi, S. J. Singh, O. M. Singh. An efficient transesterification of β-oxodithioesters catalyzed by stannous chloride under solvent-free conditionsTetrahedron Letters. 201354, 1432.

  28. O. M. Singh, L. R. Devi. Stannous chloride as a versatile catalyst in organic synthesisMini-Reviews in Organic Chemistry. 201310, 84-96

  29. O. M. Singh, L. R. Devi, N. Das. Synthesis of 2,6-diaminopyridine substituted α-oxoketene S,N-acetals: Crystal structure and hydrogen bonding interactionsJournal of Chemical Sciences. 201315, 1103-1107

  30. N. S. Devi, T. P. Singh, N. Khumanthem, O. M. Singh. Synthesis of chromene-2-thiones and in vitro evaluation of their antifungal and antibacterial activitiesIndian Journal of Chemistry201352B, 1224-1231.

  31. L. R. Singh, O. M. Singh. Datura stramonium: An overview of its phytochemistry and pharmacognosy, Research Journalof Pharmacognosy and Phytochemistry. 2013, 5, 143-148.

  32. N. S. Devi, S. J. Singh, O. M. Singh. letter An Efficient One-Pot Multicomponent Synthesis of 2, 3-Dihydro-3-alkyl/aryl-2-thioxoquinazolin-4 (1H)-ones under Solvent-Free Conditions, Synlett201223, 2111.

  33. L. R. Devi, O. M. Singh. Facile synthesis of spiro-fused heterocyles by multicomponent reactions under solvent-free conditions, Indian Journal of Chemistry, Sect. B201251B, 1426.

  34. M. J. Hwang, J. H. Park, E. B. Jeong, I. Kang, D. H. Lee, C. E. Park, O. M. Singh, H. J. Choi, Y.-H. Kim, Y. J. Yoon, S.-K. Kwon, S.-G. Lee. A first synthesis and physical properties of asymmetric anthracenes-thiophenes bridged with ethyleneBulletin of Korean Chemical Society. 201233, 3810 – 3816.

  35. O. M. Singh, L. R. Devi, T. P. Singh, H. Ila. Intramolecular cyclocondensation of a-oxoketene N, N-, N, S-and N, O-acetals: synthesis of novel pyrido [1, 2-a] pyrimidinium tetrafluoroborates, Arkivoc. 2011, (ii), 297-309.

  36. O. M. Singh, N. S. Devi, L. R. Devi, K. B. Lim, Y. J. Yoon, S.-G. Lee. Facile Synthesis of 3-Thioxo-3H-benzo [f] chromen-2-yl methanone and 3H-Benzo [f] chromene-3-one Under Solvent Free ConditionBulletin of Korean Chemical Society201132, 175-178.

  37. O. M. Singh, N. S. Devi. Stannous Chloride–Promoted Synthesis of S-Allyl-N-aryl Dithiocarbamates under Solvent-Free ConditionsSynthetic Communications. 201141, 516–522.

  38. T. P. Singh, O. M. Singh, H. B. Singh. Adhatoda vasica Nees: phytochemical and pharmacological profileThe Natural Product Journal. 20111, 29-39.

  39. T. P. Singh, O. M. SinghPhytochemical and pharmacological profile of Zanthoxylum armatum DC.-an overviewIndian Journal of Natural Products and Resources, 20111, 275–285.

  40. O. M. SinghOrganic reactions in microwave conditions, Journal of Applied Chemistry, 20112, 35-37.

  41. O. M. Singh, T. P. Singh. Phytochemistry of Solanum Xanthocarpum: an amazing traditional healer, Journal of Scientific &Industrial Research. 201069,732-740.

  42. O. M. Singh, T. P. Singh. Friedel-crafts reactions of Indole under Solvent-free Conditions, Journal of Applied Chemistry. 20101, 7-11.

  43. O. M. Singh, N. S. Devi, L. R. Devi, N. Khumanthem. Cupric Chloride Catalysed Synthesis of 5-methylmercaptothiocarbonyl-4-aryl-3,4-dihydropyrimidin-2(1H)-ones under Solvent-free Condition and their Antimicrobial ActivitiesInternational Journal of Drug Design and Discovery 20101, 258–264.

  44. O. M. Singh, N. S. Devi, D. S. Thokchom, G. J. Sharma. Novel 3-alkanoyl/aroyl/heteroaroyl-2H-chromene-2-thiones: Synthesis and evaluation of their antioxidant activitiesEuropean Journal of Medicinal Chemistry. 201045, 2250–2257.

  45. O. M. Singh, L. G. Chanu, S. H. Jang, S.-G. Lee. Regioselective synthesis of heterocyclic ketene N, N-, N, O-and N, S-acetals in aqueous mediumBulletin of Korean Chemical Society201031, 859-862.

  46. O. M. Singh, S. H. Jang, T. B. Tai, J. H. Park, H. J. Jeong, E. J. Chun, Y.-H. Kim, S.-G. Lee, Y. J. Yoon, S. K. Kwon. Synthesis and Characterization of Highly Conjugated Cyclopenta[def]phenanthrene-Based Polymers, Macromolecular Research. 2010, 18,185-191.

  47. O. M. Singh, T. P. Singh, N. S. Devi, L. G. Chanu. Metal Catalyzed Reactions: Synthesis of Bioactive Compounds and C-C Bond Forming Reactions, Organic Chemistry: An Indian Journal. 2009, 5195-198.

  48. O. M. Singh, N. S. Devi. Application of β-Oxodithioesters in domino and multicomponent reactions: Facile route to dihydropyrimidines and coumarins, Journal of Organic Chemistry. 2009, 743141-3144.

  49. O. M. Singh, S. J. Singh. Cupric chloride promoted regioselective C-allylation of enaminones, Tetrahedron Letters200849, 3991-3994.

  50. O. M. Singh, S. J. Singh, M. B. Devi, L. N. Devi, N. I. Singh, S.-G. Lee. Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones, Bioorganic and Medicinal Chemistry Letters. 200818, 6462-6467.

  51. O. M. Singh, S. J. Singh. Cupric chloride promoted regioselective C-allylation of enaminones, Tetrahedron Letters200849, 3991-3994

  52. O. M. Singh, W. M. Singh, K. S. Devi. Isolation and characterization of triterpene lactones from Phlogacanthus thyrsiflorus Nees (Acanthaceae), Natural Products: An Indian Journal. 20084, 71-73.

  53. O. M. Singh, M. L. Singh, S. J. Singh. SnCl2-Catalyzed Synthesis Of Dihydropyrimidinones Under Solvent-Free ConditionsHeterocyclic Communications200713, 277-282.

  54. O. M. Singh, M. F. Ahmad, S. J. Singh, S.-G. Lee. Synthesis of Amino Substituted Pyrazoles, Journal of Chemical Research2007, No.4, 229–232.

  55. O. M. Singh, H. J. Jeong, S. C. Shin, Y.-J. Yoon, S.-G. Lee. A new Zn/TiCl4/LiAlH4 mediated approach to 2-aryl-or 2-alkyl-substituted benzothiophenes via intramolecular cyclization, Synlett20079, 1407-1410.

  56. O. M. Singh, K. Subharani, N. I. Singh, N. B. Devi, Nevidita L. Isolation of steroidal glycosides from Solanum xanthocarpum and studies on their antifungal activitiesNatural Product Research2007, 21, 585–590.

  57. O. M. Singh, S. J. Singh, S. N. Kim, S.-G. Lee. Reaction of Lithioamines with Alkyl Halides: A Convenient Direct Synthesis of N-AlkylaminopyridinesBulletin of Korean Chemical Society200728, 115-117.

  58. O. M. SinghSynthesis of Amino Substituted PyrazolesJournal of Scientific & Industrial Research. 200665, 956-965.

  59. O. M. SinghS. J. Singh. A facile one-pot synthetic method for 1,2,4-triazoles and 1,3-disubstitued thioureas, Journal of Chemical Research. 20063, 483-485.

  60. N. Das, O. M. Singh, A. Ghosh, P. J. Stang. Facile Synthesis of Enantiopure Chiral Molecular Rectangles Exhibiting Induced Circular DichroismOrganic Letters. 20068, 1701-1704.

  61. O. M. Singh, M. F. Ahmed, Dinesh, H. A facile synthesis of pyrrolo[1,2-a]imidazoles and pyrrolo[1,2-a]pyrimidinesIndian Journal of Heterocyclic Chemistry200515, 87-88.

  62. O. M. SinghReport of ACS National Meeting & Expositions, Current Science2005891658-1659.

  63. O. M. Singh, M. F. Ahmed. Cyclocondensation of cyanoketene dithioacetal with 2-aminopyridine: Synthesis of pyrido [1, 2-a]pyrimidinesIndian Journal of Chemistry, Sect B: 200443B, 1561-1564.

  64. O. M. Singh, O. Barun, H. Ila, H. Junjappa, A Facile Access to 2-Methylthio/Alkoxy/Amino-3-acylimidazo[1,2-a]pyridines Based on Cupric Chloride Promoted Oxidative Ring Closure of α-Oxoketene N,S-, N,O-, and N,N-AcetalsJournal of Organic Chemistry2000, 65, 1583-1587.

  65. O. M. Singh, H. Ila, H. Junjappa. A facile synthesis of 3-cyclopropyl- and 5-cyclopropylisoxazoles, Journal of Chemical Research. 1999, 6, 398-399.

  66. O. M. Singh, O. Barun, H. Ila, H. Junjappa. Reaction of β-oxodithioesters with propargylamine: a facile entry to novel 2-(acylalkylidene)-5-(methylene)thiazolidines, Synthetic Communications. 199828, 3073-3079.

  67. O. M. SinghSynthesis of novel 3-cyano-4-methylthio-6-(arylcyclopropyl)-3-(1H)-pyridones and 5(3)-methylthio-3(5)-(arylcyclopropyl)pyrazolesIndian Journal of Chemistry, Section B: 199736B, 1056-1058

  68. O. M. SinghReaction of α -bis(methylthio)methylene cyclopropyl ketones with guanidine: synthesis of 2-amino-4-alkoxy-6-(arylcyclopropyl)pyrimidinesIndian Journal of Chemistry, Section B: 199736B, 1123-1125.

  69. O. M. SinghReaction of lithioamino anions with α-oxoketene dithioketals: an improved and a new general method for the synthesis of α-oxoketene S,N- and N,N-ketals, Journal of the Chemical Society, Perkin Transactions 1: (Org. Biomol. Chem.)199723, 3561-3565.

  70. O. M. SinghA new general route to 1,2-diarylethylenes,1,4-diarylbutadienes and 1,6-diarylhexatrienes through cycloaromatization of β-oxodithioacetals, Synthesis. 199211, 1075-1077.




  • Book chapters

  1. L. R. Devi, O. M. Singh. Application of silica-based heterogeneous catalysis for the synthesis of bioactive heterocycles as Book Chapter in Heterogeneous Catalysis. CRC Press (Taylor & Francis), K. L. Ameta and Andrea Penoni eds, 2014, Chapter 6, 163 -190, ISBN: 978-1-4665-9482-1.

  2. L. R. Devi, O. M. Singh. One pot reaction for the synthesis of coumains under solvent-free condition as Book Chapter Current Topics in Redox Biology, G. J. Sharma & R. N. Sharan eds. McGraw Hill Education (India) Private Limited, New Delhi, 2014, 290-297 (ISBN-13: 978-93-392-1420-3).

  3. T. P. Singh, O. M. Singh. Synthesis and bioactivity of dihydropyrimidines as Book Chapter in Bioactive Heterocycles, Nova Science Publishers Inc, USA, K. L. Ameta, R. P. Pawar & A. J. Domb eds, 2012, Chapter 6, 117-135.(ISBN: 978-1-62257-637-4).

  4. O. M. Singh. Dithiocarboxylates and related compounds in the synthesis of heterocycles as Book Chapter in Targets in Heterocyclic Systems: Chemistry and Properties 2012, Vol.16, 265-308. Attanasi, Orazio A.; Spinelli, Domenico (Eds.), Royal Society of Chemistry Jointly published with Società Chimica Italiana, ItalySoftcover (also known as softback) version . (ISBN 978-88-86208-52-9).

  • Some invited lectures delivered in international and national conferences:

  1. Presented a research finding in Monitoring of Ongoing Organic Chemistry EMR Proposal IISER, Bhopal on 26th August, 2018. Topic: “β-Oxodithioesters in the synthesis of combinatorial library of indole alkaloids and studies on their anticancer activities”

  2. Presented an Invited Talk: “Synthesis and Photophysical Properties of New Indole Derivatives in an International conference, OrganiX-2018, held in University of Tezpur, Assam, on December 20-21, 2018.

  3. International Society of Heterocyclic Chemistry (ISHC), annual conference at University of Regensberg, Germany, during September 3-8, 2017. International conference on Heterocycles ISHC 26. Talk: “Small Libraries of Bioactive Heterocycles from Dithiocarboxylates

  4. UGC Sponsored National Seminar, Topic: Emerging trends in Chemical Sciences-2018.Held on 29th January, 2018 at Gauhati University. Invited Talk: “SiO2-HClO4: Synthesis, characterization and applications as reusable heterogeneous catalyst in the synthesis of bioactive heterocycles”

  5. International Conferenmce held on 27-29th March, 2017 at Life Sciences Department, Manipur University. Topic: International Conference on Natural; resources Management and Technology Trends. Invited Talk

  6. Indole derivatives and indole based alkaloids from dithiocarboxylates” Recent Trends in Affordable and Sustainable Drug Discovery and Developments, 22nd Indian Society of Chemists and Biologists Conference (ISCBC-2016), 6-8 February, 2016 at Uka Tarasadia University, Surat, India.

  7. Synthesis of coumarins and indole derivatives using β-OxodithioestersAn international symposium on recent advances in chemistry (REACH-2015) in the Department of Chemistry, North-Eastern Hill University, March 03 – 05, 2015.

  8. Presented a poster entitled A novel threecomponent and tandem synthesis of imidazo[1,2a]pyridines and pyrido[1,2a]pyrimidines in water” 14th Tetrahedron Symposium, 25-28th June, 2013 at Vienna, Austria.

  9. Diversity Oriented Synthesis: Libraries of Bioactive Heterocycles and Evaluation of Various Biological Activities in the CRSI East Zone Meeting, International Year of Chemistry 2011 (IYC 2011) Department of Chemistry, University of North Bengal, July 22 – 24, 2011.

  10. β-Oxodithioesters in Diversity Oriented Synthesis: Designing Combinatorial Libraries of Bioactive Heterocycles in the National Symposium on “Organometallic Chemistry & Organic Synthesis: Highlights and New Perspectives(OMCOS)”, in the Department of Chemistry, North-Eastern Hill University, March 28 – 29, 2011.


  • Members of Scientific Associations:

  1. Life Member of Indian Science Congress, India.

  2. Life Member of CRSI, Bangalore, India.

  3. Life Member of Indian Association of Chemists and Biologist (ISCB), CDRI Lucknow, India & Zonal Secretary of North East, ISCB

  4. Life Member of Indian Council of Chemists (ICC), Agra, India

  5. Life Member of Indian Association of Chemistry Teachers (IACT), Mumbai, India.

  6. Annual Member of American Chemical Society (ACS), USA.

  7. Annual Member of International Society of Heterocyclic Chemistry (ISHC), USA


  • Research Projects (on-going) during the current year:


  1. DBT, NER Twinning project Title: Extraction of Bioactive Compounds & development of Pesticide Formulations from aromatic Plants available in North Eastern Region

No. BT/25414/NER/95/1183/2017.