Manipur University

Biotechnology Department

Faculty Member: Dr Lisam Shanjukumar Singh

Profile

Designation	Reader & Head
Specialization	Cancer Biology & Molecular Biology
email	shanju_lisam@hotmail.com
Highest Degree	Ph D
Honours/Awards	1. Achievement for Excellence in Cancer Research (2006)- Indiana University, Indianapolis, USA 2. Innovation award for "Development of a Method for the Inhibition of Metastasis"(2004) -The Cleveland Clinic, Ohio, USA
Research Projects	4
Research Papers	10+
Website	http://www.lisamcancerlab.in

Brief Introduction

Dr Lisam Shanjukumar is an Associate Professor and Head of the Department of Biotechnology, Manipur University. He joined Manipur University 2009 as the founder head of the department. He did his post doctoral research in the Cancer Biology Department, Cleveland Clinic, Ohio, and Indiana University , Indianapolis, USA. He made contribution in the field of cancer metastasis. He identified a novel metastasis suppressor gene (MSG) for prostate cancer(Science Daily , Aug. 28, 2007). He has also demonstrated for the first time that an intronless gene version of casein Kinase alpha is expressed in a chronic myelogenous leukemic cell.

Research Papers:

Abnormalities in osteoclastogenesis and decreased tumorigenesis in mice deficient for ovarian cancer G protein-coupled receptor 1.
Li H, Wang D, Singh LS, Berk M, Tan H, Zhao Z, Steinmetz R, Kirmani K, Wei G, Xu Y
PLoS One. 2009 May 28;4(5):e5705. PubMed PMID: 19479052; PubMed Central PMCID: PMC2684630. (Impact Factor 4.411)

Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer.
Singh LS, Berk M, Oates R, Zhao Z, Tan H, Jiang Y, Zhou A, Kirmani K, Steinmetz R, Lindner D, Xu Y.
J Natl Cancer Inst. 2007 Sep 5;99(17):1313-27. Epub 2007 Aug 28. PubMed PMID: 17728215. (Impact Factor 14.16)

Homo- and hetero-dimerization of LPA/S1P receptors, OGR1 and GPR4.
Zaslavsky A, Singh LS, Tan H, Ding H, Liang Z, Xu Y.
Biochim Biophys Acta. 2006 Oct;1761(10):1200-12. Epub 2006 Aug 30. PubMed PMID: 17023202. (Impact Factor 4.663)

Lysophosphatidic acid is constitutively produced by human peritoneal mesothelial cells and enhances adhesion, migration, and invasion of ovarian cancer cells.
Ren J, Xiao YJ, Singh LS, Zhao X, Zhao Z, Feng L, Rose TM, Prestwich GD, Xu Y.
Cancer Res. 2006 Mar 15;66(6) :3006-14. PubMed PMID: 16540649. (Impact Factor 8.234)

KiSS1 suppresses metastasis in human ovarian cancer via inhibition of protein kinase C alpha.
Jiang Y, Berk M, Singh LS, Tan H, Yin L, Powell CT, Xu Y.
Clin Exp Metastasis. 2005; 22(5):369-76. PubMed PMID: 16283480. (Impact Factor 4.113)

The contribution of amino acid region ASP695-TYR698 of factor V to procofactor activation and factor Va function.
Beck DO, Bukys MA, Singh LS, Szabo KA, Kalafatis M.
J Biol Chem. 2004 Jan 23;279(4):3084-95. Epub 2003 Oct 14. PubMed PMID: 14559913. (Impact Factor 4)

Amino acids Glu323, Tyr324, Glu330, and Val331 of factor Va heavy chain are essential for expression of cofactor activity.
Singh LS, Bukys MA, Beck DO, Kalafatis M.
J Biol Chem. 2003 Jul 25;278(30):28335-45. Epub 2003 May 8. PubMed PMID: 12738785.(Impact Factor 4)

Sequencing of full-length cDNA encoding the alpha and beta subunits of human casein kinase II from human platelets and megakaryocytic cells. Expression of the casein kinase IIalpha intronless gene in a megakaryocytic cell line.
Singh LS, Kalafatis M.
Biochemistry. 2002 Jul 16;41(28):8935-40. PubMed PMID: 12102635. (Impact Factor 3.226).

Purification and characterization of intestinal adenosine deaminase from mice.
Singh LS, Sharma R
Mol Cell Biochem. 2000 Jan;204 (1-2):127-34. PubMed PMID:10718633. (Impact Factor 2.168)